3/25/05

CURRICULUM VITAE

Mary I. Townsley

PERSONAL INFORMATION

Current Position: Assistant Dean, Office of Faculty Affairs

Professor, Department of Physiology

Professional Address: Office of Faculty Affairs

College of Medicine, CSAB 170

University of South Alabama

Mobile, Alabama 36688

Phone: (251)460-7708 or 6815

FAX: (251)460-6386

Email: mtownsley@usouthal.edu

Citizenship: USA

EDUCATION

Postdoctoral training, University of South Alabama, Mobile, Alabama, 1983-1986

Ph.D., Physiology, University of California, Davis, California, 1982

B.A., Biology, Lycoming College, Williamsport, Pennsylvania, 1972

PROFESSIONAL QUALIFICATIONS

Positions Held:

Assistant Dean, Office of Faculty Affairs, 2004-present, University of South Alabama College of

Medicine, Mobile, Alabama

Director, Training Programs, Center for Lung Biology, 2002-present, University of South

Alabama College of Medicine, Mobile, Alabama

Director, Interdisciplinary Graduate Program in Basic Medical Sciences, 2001-2004, University

of South Alabama College of Medicine, Mobile, Alabama

Professor, Department of Physiology, 1995-present, University of South Alabama College of

Medicine, Mobile, Alabama

Director of Graduate Studies, 1995-1996, University of South Alabama College of Medicine,

Mobile, Alabama

Associate Professor, Department of Physiology, 1991-1995, University of South Alabama

College of Medicine, Mobile, Alabama (Promotion and tenure granted in 1991)

Assistant Professor, Department of Physiology, 1988-1991, University of South Alabama

College of Medicine, Mobile, Alabama

Assistant Professor, Department of Physiology, 1986-1988, Northeastern Ohio Universities

College of Medicine, Rootstown, Ohio

Visiting Assistant Professor, Department of Animal Physiology, 1983, University of California,

Davis, California

Professional Society Memberships:

American Physiological Society, Elected Fellow of the Cardiovascular Section, 1993

American Heart Association, Elected Fellow, AHA Council on Cardiopulmonary,

Perioperative and Critical Care, 2003

American Thoracic Society

Society for Executive Leadership in Academic Medicine

Microcirculatory Society

European Microcirculation Society

Sigma Xi

Honors:

Alpha Omega Alpha Medical Honor Society, Elected 2000

1999-2000 Class of Fellows in the Hedwig van Ameringen Executive Leadership in

Academic Medicine (ELAM) Program for Women

Travel Award for 31st IUPS, American Physiological Society, 1989

Draco Award, Microcirculation Society, 1987

Loren D. Carlsen Award in Physiology, University of California, Davis, 1983

Professional Activities:

Editorial Boards

Clinical Science, 2000-2001

Microcirculation, 1999-2002

American Journal of Physiology, Heart and Circulatory Physiology, 1997-1998

Microvascular Research, 1997-present

Ad Hoc Journal Reviews

Acta Physiologica Scandinavica

American Journal of Physiology

American Journal of Respiratory and Critical Care Medicine

Anesthesiology

Basic Research in Cardiology

Circulation Research

Hypertension

Journal of Applied Physiology

Journal of Clinical Investigation

Journal of Pharmacology and Experimental Therapeutics

Study Sections

NIH ZRG1 RES B (02), October, 2004; Chair

AHA Lung, Respiration and Resuscitation National Study Committee,

Chair, 2001-2003; Co-Chair, 1997-1998, 2000

VA Merit Review Subcommittee for Respiration, 1998-2000

Chair, Committee 4 AHA Southern Research Consortium, 1997-1998

NIH Physiological and Biological Sciences Special Emphasis Study Section, 1996

AHA Lung and Development Study Committee, 1994-1997

NIH General Medicine A Study Section, 1994

NIH Physiological Sciences Study Section, 1994

NIH Clinical Sciences Study Section; Ad Hoc 1990, 1992; Member 1992-1994

Alabama Heart Association Grant Review Board, 1991-1994

Co-Chair, 1994

Ohio Thoracic Society Grant Review Board, Ad Hoc 1987

National Committees

AHA National Research Committee, 2000-2005

AHA Steering Committee, 2004-2005

AHA Southeast Affiliate

Chair, Research Committee, 2002-2004

Vice Chair, Research Committee, 2000-2002

Board of Directors, 2002-2004

AHA Council on Cardiopulmonary and Critical Care

Vice Chair, 2003-2005

Chair, Communications Sub-committee, 2000-2003

Research Committee Representative, 2000-2005

Member, ECC Sub-committee, 2000-2002

Executive Committee, 1996-2005

Newsletter Editor, 1996-2001

Gulf Coast Physiological Society

President, 2002-2004

Microcirculatory Society

Publications Committee, 1996-1999

Executive Council, 1993-1996

American Physiological Society

Cardiovascular Section Nominating Committee (elected), 2002-2005

Women in Physiology Committee, 1996-1998

Program Committee, Cardiovascular Section, 1995-1998

Career Opportunities in Physiology Committee, 1988-1991

Mentor, NIDDK/APS Minority Fellows Program, 1988, 1989, 1997

University Committees

Conflict of Interest Committee, 2001-2004

University Research Council, 2001-2004

University Graduate Council, 2001-2004

SACS Self Study, Educational Program/Graduate Committee, 2000-2001

Chair, Subcommittee 1

Cost Accounting Standards Committee, Cost Sharing Subcommittee, 2000

University Fringe Benefits Committee, 2000-2002

Faculty Senate Salary and Benefits Committee, 1999-2001 (Chair, 2000-2001)

Faculty Grievance Committee Pool, 1999-2005

Coordinator, USA Women in Science Faculty Group, 1998-2000

Senate Handbook Committee, 1988-1989

Faculty Senate, 1988-1989; 1999-2002

College of Medicine Committees

Chair, Faculty Committee on Appointments, Promotions, and Evaluations, 2002-

2006; Member 1995-1998; 2001-2002

Chair, Research Advisory Committee, 2001-2004

Chair, LCME Self-Evaluation Subcommittee on Graduate Education in the

Science Basic to Medicine, 2001-2002

Cancer Institute: Basic/Translational Research Task Force, 2001

Internal Advisory Committee, USA Comprehensive Sickle Cell Center, 2001

Ad Hoc Committee for Development of Policy on “Standards in Conduct in the

Teacher-Learner Relationship”, 2001

Chair, Task Force on Research Organization and Performance Evaluation, 2000

Faculty Assembly, Vice-President, 1995-1997; President, 1997-1998;

Past-President, 1998-1999

Minority Affairs Advisory Committee, 1994-present

LCME Self-Evaluation Task Force, 1994-1995

Chair, Evaluation of Medical Education Subcommittee, LCME Task

Force, 1994-1995

Secretary, Basic Medical Sciences Faculty, 1992-1993

BEAR Committee, 1991-1992, 1998-2001

Committee on Standards in the Conduct of Research, 1991-1994

Basic Medical Science Student Organization, Faculty Advisor, 1991

Committee on Admissions, 1990-1993

Scholarship Subcommittee, 1990-1992

Distinguished Scientists Seminar Program, 1989-1991

Student Promotions and Evaluations, 1989-1991

Institutional Animal Care and Use, 1989-1990

Student Research, 1988-1992 (Chair 1990-1992), 1998-2001

Department of Physiology Responsibilities

Medical Physiology, Course Director, 1992-1995, 2001-2004

Course Director, Medical Physiology, Biomedical Enrichment and Recruitment

Program, 1997-2001

Graduate Coordinator, 1988-1996

College of Medicine Basic Medical Science Graduate Program Service

Director, 1995-1996, 2001-2004

Curriculum Committee, 2000-2001

Student Performance and Evaluations Committee, 1999-2000

Graduate Executive Committee

Chair, 1995-1996, 2001-2004

Member-at-large 1997-1998, 2000-2001

Graduate Admissions Committee

Chair, 1995-1996, 2001-2004

Other Service

Chair, Review Team for Department of Veterinary Physiology & Pharmacology,

Texas A&M University, Review of Doctoral Programs, 2001

Council Delegate, American Heart Association Delegate Assembly, 2001

Organizing Committee, Expanding Your Horizons, 2001-2003

Organizing Committee, Regional Science Olympiad, 2000-2002

Reviewer, American Heart Association Position Statement on “Cardiovascular

Disease in Women”, 1997

Judge, Regional Science Fair, 1997-1999

Board of Directors, American Heart Association, Southeast Affiliate, Mobile

County Division, 1995-1998

Youth Summit Advisory Committee, Alabama Cooperative Extension System,

Mobile, 2001

GRANT FUNDING

Active Awards

NIH/NHLBI (T32 HL076125): "Training in cell signaling and lung pathobiology"; 2004-2009; Total direct costs $796,231; Program director.

NIH/NHLBI (R01 HL39045): "T-lymphocyte involvement in lung ischemia-reperfusion injury”, 2003-2005; Total direct costs $400,000; Principal investigator

American Heart Association, Southeast Affiliate, Predoctoral Fellowship (Alvarez - 0315049B): “Role of P450 arachidonic acid metabolites in regulation of pulmonary endothelial cell permeability”; 2003-2005; Total direct costs $36,000; Sponsor

NIH/NHLBI (RO1 HL61955): “Heart failure-induced alterations in regulation of pulmonary endothelial permeability”, 1999-2003; Total direct costs $680,274; Principal investigator (current no cost extension)

Previous Awards

NIH/NHLBI (R01 HL39045): "Lung microcirculation with high vascular pressures", 1996-2000; Total direct costs $560,984; Principal investigator

American Heart Association Grant-in-Aid, Southeast Affiliate (9810109): “Peripheral microvascular permeability response to autocoids in heart failure: role of catecholamines and prostanoids”, 1998-2000; Total direct costs $66,071; Collaborating investigator; D. Lynn Dyess, M.D., Principal investigator

American Heart Association Grant-in-Aid, National Center (96015130): "Lung microcirculation with high vascular pressures”, 1996-1999; Total direct costs $120,000; Principal investigator (awarded but declined)

American Physiological Society, Porter Physiology Development Program; Predoctoral Fellowship for Ron McMillon, 1994-1996; Total direct costs $13,500; Faculty mentor

American Heart Association Established Investigatorship (92001990): "Lung remodeling in chronic pulmonary venous hypertension", 1992-1997; Total direct costs $265,000; Principal investigator

NIH Research Career Development Award (K04 HL02732): "Lung adaptation to chronic pulmonary hypertension", 1992-1997; Total direct costs $247,700; Principal investigator; relinquished April, 1992 to accept Established Investigatorship

NIH research grant (R01 HL39045): "Lung microcirculation with high vascular pressures", 1992-1995; Total direct costs $324,498; Principal investigator

American Heart Association Grant-in-Aid, National Center (91006760): "The pulmonary circulation in congestive heart failure", 1991-1994; Total direct costs $120,000; Principal investigator

NATO Travel grant for research collaboration : "Measurement of microvascular permeability in skin, lung, and ileum", 1989-1993; Total direct costs $15,500; Co-investigator with Dr. Rolf K. Reed, University of Bergen, Norway

ECFMG Foreign Faculty Fellowship for Dr. Vijay Devi Mathur, Professor of Physiology Kakatiya Medical College, Warangal, India, 1989-1990; Total direct costs $4,004; Co-director

NIH FIRST Award (R29 HL39045): "Lung capillary permeability with high vascular pressure", 1987-1992; Total direct costs $343,083; Principal investigator

American Heart Association, Alabama Affiliate: "Lung permeability: mechanical stress in traumatized lungs", 1986-1987; Total direct costs $15,125; Principal investigator

NIH New Investigator Award (R23 HL36332): "Lung capillary permeability with high vascular pressure", 1986-1987; Total direct costs $33,250; Principal investigator

Research Challenge (intramural award): "Contribution of blood cell components to lung injury", 1986-1987; Total direct costs $5,500; Principal investigator

Fellowship Awards --

NIH Postdoctoral Fellowship, 1984-1986

Parker B. Francis Pulmonary Fellow, 1983-1984

NIH Predoctoral Fellowship, University of California, Davis, 1979-1982

TEACHING EXPERIENCE

Biomedical Enrichment and Recruitment Program: Medical Physiology, lectures in endocrinology (6/year); 1992-2002

Graduate courses: Advanced Gastrointestinal Physiology, lectures in gut smooth muscle and motility, gastrointestinal endocrinology; Advanced Cardiovascular Physiology, lectures in smooth muscle and vascular function, control of organ blood flow, microvascular permeability, lymphatics, interstitium; Advanced Respiratory Physiology, lectures in pulmonary circulation and permeability, Computer Applications in Research, lectures and tutorials in the use of common software packages for spreadsheets, data base management, and graphics; Fundamentals in Basic Medical Sciences; Lung Biology; Lung Pathobiology; Biostatistics and Experimental Design

Medical school course: Medical Physiology, lectures in biophysics (1988-89), gastrointestinal physiology (1988-91), endocrinology (1990-2002); and neurophysiology (2002-present); 10-34 lectures/ year); also laboratories in respiratory and cardiovascular physiology

SEMINARS AND INVITED LECTURES (last 5 years)

2004 Remodeling of lung endothelial barrier function in heart failure. Pulmonary Division Research Seminar Series, University of South Alabama

TRPs and leaks in lung endothelium: A novel role for TRPV4, a vanilloid receptor TRP channel. Cell Signaling Seminar Series, University of South Alabama

TRPV4 - The "other" TRP channel. Center for Lung Biology Research in Progress, University of South Alabama.

Remodeling of lung endothelial barrier function in heart failure – A role for EETs and SOC? Department of Physiology, LSU Health Sciences Center, New Orleans

2003 Remodeling of lung endothelial barrier function in heart failure – A role for EETs and SOC? Cardiovascular Center, Medical College of Wisconsin

Pulmonary interstitium. Grand Rounds, Department of Surgery, University of South Alabama

Pressure tactics: The lung and pulmonary hypertension. The Odyssey Program, University of South Alabama

2002 Remodeling of alveolar-capillary barrier in chronic pulmonary venous hypertension. ATS Symposium: Mechanical factors in postnatal lung growth and remodeling

2001 Altered regulation of pulmonary endothelial permeability in chronic heart failure: A role for P450 epoxygenases?; Pulmonary Division, Northwestern University School of Medicine

The lung in heart failure: a tale of form and function. Department of Physiology, University of South Alabama

Functional and structural lung remodeling in congestive heart failure, American Thoracic Society Assembly Workshop on Mechanisms and Limits of Lung Growth, San Francisco

Pulmonary adaptations in chronic heart failure, Heart Failure Division, Medtronic, Inc., Minneapolis

INVOLVEMENT IN TRAINING

Undergraduate research

Emile Addison (USA), Dept. of Biology Honors Program, 2005

Brandy Merritt (USA), 2002

Beth Phillips (Spring Hill College), 2001 and 2002

Michael Stallworth (USA), 1999

Anne Barañano (Haverford College), 1999

Darlene Moyer (Lycoming College), 1999

Shari Leuwerke (St. Olaf’s College), 1998

James Lakey (USA), 1996

Darren Waters (USA), 1994

Marirose Jordan (USA), 1993

Rupa Kothandapani (USA), 1992

Master's degree in Biology

Margery Halstead (M.S., 1993); Pulmonary vascular responses to ACh and bradykinin in

pacing-induced heart failure

Mentor, Ph.D. in Physiology

Diego Alvarez (2001-projected completion spring 2005); Alterations in pulmonary

endothelial permeability after heart failure

Ronald McMillon (Ph.D., 1998); Reactivity of canine bronchial vasculature in normal

lung compared to that following the development of heart failure

Allen Lee (1994-1995); Mechanisms for attenuation of alveolar edema with chronic

pulmonary venous hypertension

Service on other Ph.D. Committees

Patti Sadowsky (Pharmacology); Epitope mapping of monoclonal antibodies to the

FK506 binding immunophilin FKBP51

Qining Qin (Physiology, Ph.D. 2004); Signal transduction pathways in myocardial

preconditioning

Wesley Denny (Pharmacology, Ph.D. 2003); Role of an FK506 binding immunophilin in

glucocorticoid resistance of the squirrel monkey

Kathy Ault-Ziel (Pharmacology, Ph.D., 2002); Hypoxia and matrix remodeling

Natalie Norwood (Pharmacology, Ph.D., 2001); Gating of Trp-1 by F-actin cytoskeleton

David Killilea (Pharmacology, Ph.D., 2000); Oxidant DNA damage and signal

transduction in lung tissue

Cherry Ballard (Pharmacology, Ph.D., 1998); Signal transduction mechanism for the

stimulation of the cardiac Na⁺-Ca²⁺ exchanger by insulin

Peter Wilson (Physiology, Ph.D., 1998); Mechanisms of pulmonary vascular tone

regulation by nitric oxide in isolated rat lungs

Ling Zhao (Pharmacology, Ph.D. , 1997); Molecular characteristics of

phosphodiesterases in pulmonary microvascular endothelium

Hafeez Diwan (Pharmacology, Ph.D., 1997); Mechanism of regulation of rat pulmonary

microvascular endothelial cell permeability by cGMP

Tim Moore (Physiology, Ph.D., 1996); Role of cyclic nucleotides and adhesion

molecules in lung ischemia reperfusion injury

Todd Engerson ( Biochemistry, Ph.D., 1991); Role of xanthine oxidase in liver ischemia

reperfusion injury

Keith Adkins (Physiology, Ph.D., 1991); Lung ischemia reperfusion injury

Medical Student Research (Summer Research Program unless noted)

William Porr, 2003

Michael Sprague, 2001

Deborah Weiss, 2000

Jimmie Lakey, 1999

Chris Heck, 1998

Leslie Hunter, 1997 and 1 month senior elective, 1999

Marirose Jordan, 1995

Tu Tran, 1993

Ken Snell, 1992

Morgan Smith, 5 months, senior elective, 1989

Sam Bartle, 12 months, 1988-89

Esther Lim, 1987

Tuomah Sahawneh, 1986

Gena Taylor, 1984

Postdoctoral Fellows

Eli-Anne Gjerde, Ph.D. (2002-2003); Lung endothelial calcium signaling

Siobhan Tarpey, Ph.D. (1999-2003); Pulmonary endothelial function after heart failure

Darryl Sawmiller, Ph.D. (1999); Pulmonary phosphodiesterase expression after

development of heart failure

Claire Ivey, Ph.D. (1996-1998); Pulmonary interstitial and endothelial adaptations in

heart failure

Bev Roy, M.D. (1992-1996); Pulmonary vascular responses to angiotensin II

Svein Åge Rodt, M.D. (1991-92); Alterations in local hemodynamics, fluid and protein

flux, and hyaluronan washout induced by histamine and compound 48/80 in skin

DaChang Liu, M.D. (1991); Morphometric analysis of lung vasculature after the

development of pacing-induced heart failure

Zhuodao Zhao, M.D. (1990-1992); Effects of saline loading on microvascular

permeability and lymphatic washout of fluid, proteins, and hyaluronan

Vijay Mathur, M.D. (1988-89); Evaluation of pulmonary hemodyamics with angiotensin

in rabbit lung

FULL-LENGTH PUBLICATIONS

1. Riordan KK, Weiskopf RB, Townsley MI, Chadwick KR. Oxygen-linked hydrogen ion binding of canine blood. Pflüegers Arch. 1981; 390:99-101.

2. Weiskopf RB, Townsley MI, Riordan KK, Chadwick K. Comparison of cardiopulmonary responses to graded hemorrhage during enflurane, halothane, isoflurane, and ketamine anesthesia. Anes. Analg. 1981; 60:481-491.

3. Jones TA, Townsley MI, Weidner WJ. Effects of intracranial and left atrial hypertension on lung fluid balance in sheep. J. Appl. Physiol. 1982; 52:1324-1329.

4. Weiskopf RB, Townsley MI, Riordan KK, Harris D, Chadwick K. Acid-base curve and alignment nomograms for swine blood. J. Appl. Physiol. 1983; 54:978-983.

5. Townsley MI, McClure DE, Weidner WJ. Assessment of pulmonary microvascular permeability in acutely prepared sheep. J. Appl. Physiol. 1984; 56:857-861.

6. Rippe B, Townsley M, Thigpen J, Parker JC, Korthuis RJ, Taylor AE. Effects of vascular pressure on the pulmonary microvasculature in isolated dog lungs. J. Appl. Physiol. 1984; 57:233-239.

7. Parker JC, Townsley MI, Rippe B, Taylor AE, Allison RC. Increased microvascular permeability in dog lungs due to high peak airway pressures. J. Appl. Physiol. 1984; 57:1809-1816.

8. Korthuis RJ, Townsley MI, Rippe B, Taylor AE. Estimation of isogravimetric capillary pressure by a filtration method in skeletal muscle and lung. J. Appl. Physiol. 1984; 57:1817-1823.

9. Rippe B, Townsley M, Parker JC, Taylor AE. Osmotic reflection coefficient for total plasma protein in lung microvessels. J. Appl. Physiol. 1985; 58:436-442.

10. Townsley MI, Korthuis RJ, Taylor AE. Effect of arachidonic acid on the distribution of vascular resistance in the canine lung. J. Appl. Physiol. 1985; 58:206-210.

11. Korthuis RJ, Granger DN, Townsley MI, Taylor AE. Autoregulation of capillary pressure and filtration rate in isolated rat hindquarters. Am. J. Physiol. 1985; 248:H835-H842.

12. Townsley MI, Korthuis RJ, Taylor AE. Specific hemodynamic effects of PGE₂ and PGF_1" in the canine lung. Prostagl. Leukotr. Med. 1985; 20:275-282.

13. Korthuis RJ, Kerr CR, Townsley MI, Taylor AE. Microvascular pressure, surface area, and permeability in isolated hindquarters of SHR. Am. J. Physiol. 1985; 249:H498-H504.

14. Korthuis RJ, Granger DN, Townsley MI, Taylor AE. The role of oxygen-derived free radicals in ischemia-induced increases in canine skeletal muscle vascular permeability. Circ. Res. 1985; 57:599-609.

15. Taylor AE, Townsley MI, Korthuis RJ. Macromolecule transport across the pulmonary microvessel walls. Exp. Lung Res. 1985; 8:95-121. (INVITED)

16. Townsley MI, Taylor GE, Korthuis RJ, Taylor AE. Promethazine or DPPD pretreatment attenuates oleic acid-induced injury in isolated canine lungs. J. Appl. Physiol. 1985; 59:39-46.

17. Rippe B, Townsley MI, Taylor AE. Effects of plasma- and cell-free perfusates on filtration coefficient of perfused isolated canine lungs. J. Appl. Physiol. 1985; 58:1521-1527.

18. Taylor AE, Korthuis R, Townsley M. Use of lymphatic protein fluxes to assess vascular endothelial selectivity to macromolecules. Prog. Appl. Microcirc. 1985; 9:100-115.

19. Korthuis RJ, Benoit JN, Kvietys PR, Townsley MI, Taylor AE, Granger DN. Humoral factors may mediate increased rat hindqua