3/25/05         

CURRICULUM VITAE

 

Mary I. Townsley

 

PERSONAL INFORMATION

 

Current Position:                       Assistant Dean, Office of Faculty Affairs

Professor, Department of Physiology

 

Professional Address:                       Office of Faculty Affairs

                                                College of Medicine, CSAB 170                  

                                                University of South Alabama

                                                Mobile, Alabama  36688

                                                Phone: (251)460-7708 or 6815

                                                FAX: (251)460-6386

                                                Email: mtownsley@usouthal.edu

 

Citizenship:                               USA

 

EDUCATION

 

Postdoctoral training, University of South Alabama, Mobile, Alabama, 1983-1986

Ph.D., Physiology, University of California, Davis, California, 1982

B.A., Biology, Lycoming College, Williamsport, Pennsylvania, 1972

 

PROFESSIONAL QUALIFICATIONS

 

Positions Held:

Assistant Dean, Office of Faculty Affairs, 2004-present, University of South Alabama College of

  Medicine, Mobile, Alabama

Director, Training Programs, Center for Lung Biology, 2002-present, University of South

  Alabama College of Medicine, Mobile, Alabama

Director, Interdisciplinary Graduate Program in Basic Medical Sciences, 2001-2004, University

  of South Alabama College of Medicine, Mobile, Alabama

Professor, Department of Physiology, 1995-present, University of South Alabama College of

   Medicine, Mobile, Alabama

Director of Graduate Studies, 1995-1996, University of South Alabama College of Medicine,

   Mobile, Alabama

Associate Professor, Department of Physiology, 1991-1995, University of South Alabama

   College of Medicine, Mobile, Alabama (Promotion and tenure granted in 1991)

Assistant Professor, Department of Physiology, 1988-1991, University of South Alabama

   College of Medicine, Mobile, Alabama

Assistant Professor, Department of Physiology, 1986-1988, Northeastern Ohio Universities

   College of Medicine, Rootstown, Ohio

Visiting Assistant Professor, Department of Animal Physiology, 1983, University of California,

   Davis, California


Professional Society Memberships:

            American Physiological Society, Elected Fellow of the Cardiovascular Section, 1993

            American Heart Association, Elected Fellow, AHA Council on Cardiopulmonary,

                        Perioperative and Critical Care, 2003

            American Thoracic Society

            Society for Executive Leadership in Academic Medicine

            Microcirculatory Society

            European Microcirculation Society

            Sigma Xi

           

Honors:

            Alpha Omega Alpha Medical Honor Society, Elected 2000

            1999-2000 Class of Fellows in the Hedwig van Ameringen Executive Leadership in

                        Academic Medicine (ELAM) Program for Women

            Travel Award for 31st IUPS, American Physiological Society, 1989

            Draco Award, Microcirculation Society, 1987

            Loren D. Carlsen Award in Physiology, University of California, Davis, 1983

 

Professional Activities:

            Editorial Boards

                        Clinical Science, 2000-2001

                        Microcirculation, 1999-2002

                        American Journal of Physiology, Heart and Circulatory Physiology, 1997-1998

                        Microvascular Research, 1997-present

 

            Ad Hoc Journal Reviews

                        Acta Physiologica Scandinavica

                        American Journal of Physiology

                        American Journal of Respiratory and Critical Care Medicine

                        Anesthesiology

                        Basic Research in Cardiology

                        Circulation Research                                                                

                        Hypertension

                        Journal of Applied Physiology

                        Journal of Clinical Investigation

                        Journal of Pharmacology and Experimental Therapeutics

 

            Study Sections

            NIH ZRG1 RES B (02), October, 2004; Chair

AHA Lung, Respiration and Resuscitation National Study Committee,

                                    Chair, 2001-2003; Co-Chair, 1997-1998, 2000

                        VA Merit Review Subcommittee for Respiration, 1998-2000

                        Chair, Committee 4 AHA Southern Research Consortium, 1997-1998

                        NIH Physiological and Biological Sciences Special Emphasis Study Section, 1996

                        AHA Lung and Development Study Committee, 1994-1997

                        NIH General Medicine A Study Section, 1994

                        NIH Physiological Sciences Study Section, 1994

                        NIH Clinical Sciences Study Section; Ad Hoc 1990, 1992; Member 1992-1994 

                        Alabama Heart Association Grant Review Board, 1991-1994

                                    Co-Chair, 1994

                        Ohio Thoracic Society Grant Review Board, Ad Hoc 1987


            National Committees

                        AHA National Research Committee, 2000-2005

                        AHA Steering Committee, 2004-2005

                        AHA Southeast Affiliate

                                    Chair, Research Committee, 2002-2004

                                    Vice Chair, Research Committee, 2000-2002

                                    Board of Directors, 2002-2004

                        AHA Council on Cardiopulmonary and Critical Care

                                    Vice Chair, 2003-2005

                                    Chair, Communications Sub-committee, 2000-2003

                                    Research Committee Representative, 2000-2005

                                    Member, ECC Sub-committee, 2000-2002

                                    Executive Committee, 1996-2005      

                                    Newsletter Editor, 1996-2001

                        Gulf Coast Physiological Society

                                    President, 2002-2004

                        Microcirculatory Society

                                    Publications Committee, 1996-1999                  

                                    Executive Council, 1993-1996

                        American Physiological Society

                                    Cardiovascular Section Nominating Committee (elected), 2002-2005

                                    Women in Physiology Committee, 1996-1998

                                    Program Committee, Cardiovascular Section, 1995-1998

                                    Career Opportunities in Physiology Committee, 1988-1991

                        Mentor, NIDDK/APS Minority Fellows Program, 1988, 1989, 1997

 

            University Committees

                        Conflict of Interest Committee, 2001-2004

                        University Research Council, 2001-2004

                        University Graduate Council, 2001-2004

                        SACS Self Study, Educational Program/Graduate Committee, 2000-2001

                                    Chair, Subcommittee 1

                        Cost Accounting Standards Committee, Cost Sharing Subcommittee, 2000

                        University Fringe Benefits Committee, 2000-2002

                        Faculty Senate Salary and Benefits Committee, 1999-2001 (Chair, 2000-2001)

                        Faculty Grievance Committee Pool, 1999-2005

                        Coordinator, USA Women in Science Faculty Group, 1998-2000

                        Senate Handbook Committee, 1988-1989

                        Faculty Senate, 1988-1989; 1999-2002

 

            College of Medicine Committees

                        Chair, Faculty Committee on Appointments, Promotions, and Evaluations, 2002-

                                    2006; Member 1995-1998; 2001-2002

                        Chair, Research Advisory Committee, 2001-2004

                        Chair, LCME Self-Evaluation Subcommittee on Graduate Education in the

                           Science Basic to Medicine, 2001-2002

                        Cancer Institute: Basic/Translational Research Task Force, 2001

                        Internal Advisory Committee, USA Comprehensive Sickle Cell Center, 2001

                        Ad Hoc Committee for Development of Policy on “Standards in Conduct in the

                                        Teacher-Learner Relationship”, 2001

                        Chair, Task Force on Research Organization and Performance Evaluation, 2000

                        Faculty Assembly, Vice-President, 1995-1997; President, 1997-1998;

                                       Past-President, 1998-1999

                        Minority Affairs Advisory Committee, 1994-present

                        LCME Self-Evaluation Task Force, 1994-1995

                        Chair, Evaluation of Medical Education Subcommittee, LCME Task

                                       Force, 1994-1995

                        Secretary, Basic Medical Sciences Faculty, 1992-1993

                        BEAR Committee, 1991-1992, 1998-2001

                        Committee on Standards in the Conduct of Research, 1991-1994

                        Basic Medical Science Student Organization, Faculty Advisor, 1991

                        Committee on Admissions, 1990-1993

                                       Scholarship Subcommittee, 1990-1992

                        Distinguished Scientists Seminar Program, 1989-1991

                        Student Promotions and Evaluations, 1989-1991

                        Institutional Animal Care and Use, 1989-1990

                        Student Research, 1988-1992 (Chair 1990-1992), 1998-2001

 

            Department of Physiology Responsibilities

                        Medical Physiology, Course Director, 1992-1995, 2001-2004

                        Course Director, Medical Physiology, Biomedical Enrichment and Recruitment

                                     Program, 1997-2001

                        Graduate Coordinator, 1988-1996

 

            College of Medicine Basic Medical Science Graduate Program Service

                        Director, 1995-1996, 2001-2004

                        Curriculum Committee, 2000-2001

                        Student Performance and Evaluations Committee, 1999-2000

                        Graduate Executive Committee

                                    Chair, 1995-1996, 2001-2004

                                    Member-at-large 1997-1998, 2000-2001

                        Graduate Admissions Committee

                                    Chair, 1995-1996, 2001-2004

 

            Other Service

                        Chair, Review Team for Department of Veterinary Physiology & Pharmacology,

                                       Texas A&M University, Review of Doctoral Programs, 2001

                        Council Delegate, American Heart Association Delegate Assembly, 2001

                        Organizing Committee, Expanding Your Horizons, 2001-2003

                        Organizing Committee, Regional Science Olympiad, 2000-2002      

                        Reviewer, American Heart Association Position Statement on “Cardiovascular

                                    Disease in Women”, 1997

                        Judge, Regional Science Fair, 1997-1999

Board of Directors, American Heart Association, Southeast Affiliate, Mobile

                                       County Division, 1995-1998

                        Youth Summit Advisory Committee, Alabama Cooperative Extension System,

                           Mobile, 2001

 


GRANT FUNDING

 

Active Awards

NIH/NHLBI (T32 HL076125): "Training in cell signaling and lung pathobiology"; 2004-2009; Total direct costs $796,231; Program director.

 

NIH/NHLBI (R01 HL39045): "T-lymphocyte involvement in lung ischemia-reperfusion injury”, 2003-2005; Total direct costs $400,000; Principal investigator

 

American Heart Association, Southeast Affiliate, Predoctoral Fellowship (Alvarez - 0315049B): “Role of P450 arachidonic acid metabolites in regulation of pulmonary endothelial cell permeability”; 2003-2005; Total direct costs $36,000; Sponsor

 

NIH/NHLBI (RO1 HL61955):  “Heart failure-induced alterations in regulation of pulmonary endothelial permeability”, 1999-2003; Total direct costs $680,274; Principal investigator (current no cost extension)

 

Previous Awards

NIH/NHLBI (R01 HL39045): "Lung microcirculation with high vascular pressures", 1996-2000; Total direct costs $560,984; Principal investigator

 

American Heart Association Grant-in-Aid, Southeast Affiliate (9810109): “Peripheral microvascular permeability response to autocoids in heart failure: role of catecholamines and prostanoids”, 1998-2000; Total direct costs $66,071; Collaborating investigator; D. Lynn Dyess, M.D., Principal investigator

 

American Heart Association Grant-in-Aid, National Center (96015130): "Lung microcirculation with high vascular pressures”, 1996-1999; Total direct costs $120,000; Principal investigator (awarded but declined)

 

American Physiological Society, Porter Physiology Development Program; Predoctoral Fellowship for Ron McMillon, 1994-1996; Total direct costs $13,500; Faculty mentor

 

American Heart Association Established Investigatorship (92001990): "Lung remodeling in chronic pulmonary venous hypertension", 1992-1997; Total direct costs $265,000; Principal investigator

 

NIH Research Career Development Award (K04 HL02732): "Lung adaptation to chronic pulmonary hypertension", 1992-1997; Total direct costs $247,700; Principal investigator; relinquished April, 1992 to accept Established Investigatorship

 

NIH research grant (R01 HL39045): "Lung microcirculation with high vascular pressures", 1992-1995; Total direct costs $324,498; Principal investigator

 

American Heart Association Grant-in-Aid, National Center (91006760): "The pulmonary circulation in congestive heart failure", 1991-1994; Total direct costs $120,000; Principal investigator

 

NATO Travel grant for research collaboration : "Measurement of microvascular permeability in skin, lung, and ileum", 1989-1993; Total direct costs $15,500; Co-investigator with Dr. Rolf K. Reed, University of Bergen, Norway

 

ECFMG Foreign Faculty Fellowship for Dr. Vijay Devi Mathur, Professor of Physiology Kakatiya Medical College, Warangal, India, 1989-1990; Total direct costs $4,004; Co-director

 

NIH FIRST Award (R29 HL39045): "Lung capillary permeability with high vascular pressure", 1987-1992; Total direct costs $343,083; Principal investigator

 

American Heart Association, Alabama Affiliate:  "Lung permeability: mechanical stress in traumatized lungs", 1986-1987; Total direct costs $15,125; Principal investigator

 

NIH New Investigator Award (R23 HL36332):  "Lung capillary permeability with high vascular pressure", 1986-1987; Total direct costs $33,250; Principal investigator

 

Research Challenge (intramural award): "Contribution of blood cell components to lung injury", 1986-1987; Total direct costs $5,500; Principal investigator 

 

Fellowship Awards --

            NIH Postdoctoral Fellowship, 1984-1986

            Parker B. Francis Pulmonary Fellow, 1983-1984

            NIH Predoctoral Fellowship, University of California, Davis, 1979-1982

 

 

TEACHING EXPERIENCE

 

Biomedical Enrichment and Recruitment Program: Medical Physiology, lectures in endocrinology (6/year); 1992-2002

 

Graduate courses: Advanced Gastrointestinal Physiology, lectures in gut smooth muscle and motility, gastrointestinal endocrinology; Advanced Cardiovascular Physiology, lectures in smooth muscle and vascular function, control of organ blood flow, microvascular permeability, lymphatics, interstitium; Advanced Respiratory Physiology, lectures in pulmonary circulation and permeability, Computer Applications in Research, lectures and tutorials in the use of common software packages for spreadsheets, data base management, and graphics; Fundamentals in Basic Medical Sciences; Lung Biology; Lung Pathobiology; Biostatistics and Experimental Design

 

Medical school course: Medical Physiology, lectures in biophysics (1988-89), gastrointestinal physiology (1988-91), endocrinology (1990-2002); and neurophysiology (2002-present); 10-34 lectures/ year); also laboratories in respiratory and cardiovascular physiology

 

SEMINARS AND INVITED LECTURES (last 5 years)

 

2004             Remodeling of lung endothelial barrier function in heart failure.  Pulmonary Division Research Seminar Series, University of South Alabama

 

            TRPs and leaks in lung endothelium: A novel role for TRPV4, a vanilloid receptor TRP channel.  Cell Signaling Seminar Series, University of South Alabama

 

            TRPV4 - The "other" TRP channel.  Center for Lung Biology Research in Progress, University of South Alabama.

 

            Remodeling of lung endothelial barrier function in heart failure – A role for EETs and SOC?  Department of Physiology, LSU Health Sciences Center, New Orleans

 

2003            Remodeling of lung endothelial barrier function in heart failure – A role for EETs and SOC?  Cardiovascular Center, Medical College of Wisconsin

 

            Pulmonary interstitium.  Grand Rounds, Department of Surgery, University of South Alabama

 

Pressure tactics: The lung and pulmonary hypertension.  The Odyssey Program, University of South Alabama

 

2002            Remodeling of alveolar-capillary barrier in chronic pulmonary venous hypertension.  ATS Symposium: Mechanical factors in postnatal lung growth and remodeling

 

2001    Altered regulation of pulmonary endothelial permeability in chronic heart failure: A role for P450 epoxygenases?; Pulmonary Division, Northwestern University School of Medicine

 

The lung in heart failure: a tale of form and function.  Department of Physiology, University of South Alabama

 

Functional and structural lung remodeling in congestive heart failure, American Thoracic Society Assembly Workshop on Mechanisms and Limits of Lung Growth, San Francisco

 

Pulmonary adaptations in chronic heart failure, Heart Failure Division, Medtronic, Inc., Minneapolis

 

 

INVOLVEMENT IN TRAINING

 

Undergraduate research

            Emile Addison (USA), Dept. of Biology Honors Program, 2005

            Brandy Merritt (USA), 2002

            Beth Phillips (Spring Hill College), 2001 and 2002

            Michael Stallworth (USA), 1999

            Anne Barañano (Haverford College), 1999

            Darlene Moyer (Lycoming College), 1999

            Shari Leuwerke (St. Olaf’s College), 1998

            James Lakey (USA), 1996

Darren Waters (USA), 1994

            Marirose Jordan (USA), 1993

            Rupa Kothandapani (USA), 1992

                                                                                                                                   

Master's degree in Biology

Margery Halstead (M.S., 1993); Pulmonary vascular responses to ACh and bradykinin in

                pacing-induced heart failure

 

Mentor, Ph.D. in Physiology

            Diego Alvarez (2001-projected completion spring 2005); Alterations in pulmonary

    endothelial permeability after heart failure

Ronald McMillon (Ph.D., 1998); Reactivity of canine bronchial vasculature in normal

               lung compared to that following the development of heart failure

Allen Lee (1994-1995); Mechanisms for attenuation of alveolar edema with chronic

               pulmonary venous hypertension

 

Service on other Ph.D. Committees

            Patti Sadowsky (Pharmacology); Epitope mapping of monoclonal antibodies to the

               FK506 binding immunophilin FKBP51

            Qining Qin (Physiology, Ph.D. 2004); Signal transduction pathways in myocardial

   preconditioning

            Wesley Denny (Pharmacology, Ph.D. 2003); Role of an FK506 binding immunophilin in

               glucocorticoid resistance of the squirrel monkey

            Kathy Ault-Ziel (Pharmacology, Ph.D., 2002); Hypoxia and matrix remodeling

            Natalie Norwood (Pharmacology, Ph.D., 2001); Gating of Trp-1 by F-actin cytoskeleton

            David Killilea (Pharmacology, Ph.D., 2000); Oxidant DNA damage and signal

               transduction in lung tissue

Cherry Ballard (Pharmacology, Ph.D., 1998); Signal transduction mechanism for the

               stimulation of the cardiac Na+-Ca2+ exchanger by insulin

Peter Wilson (Physiology, Ph.D., 1998); Mechanisms of pulmonary vascular tone

                regulation by nitric oxide in isolated rat lungs

Ling Zhao (Pharmacology, Ph.D. , 1997); Molecular characteristics of

                phosphodiesterases in pulmonary microvascular endothelium

Hafeez Diwan (Pharmacology, Ph.D., 1997); Mechanism of regulation of rat pulmonary

               microvascular endothelial cell permeability by cGMP

Tim Moore (Physiology, Ph.D., 1996); Role of cyclic nucleotides and adhesion

   molecules in lung ischemia  reperfusion injury

Todd Engerson ( Biochemistry, Ph.D., 1991); Role of xanthine oxidase in liver ischemia

               reperfusion injury

            Keith Adkins (Physiology, Ph.D., 1991); Lung ischemia reperfusion injury

 

Medical Student Research (Summer Research Program unless noted)

            William Porr, 2003

            Michael Sprague, 2001

            Deborah Weiss, 2000

            Jimmie Lakey, 1999

            Chris Heck, 1998

            Leslie Hunter, 1997 and 1 month senior elective, 1999

Marirose Jordan, 1995

            Tu Tran, 1993

Ken Snell, 1992

Morgan Smith, 5 months, senior elective, 1989

Sam Bartle, 12 months, 1988-89

Esther Lim, 1987

Tuomah Sahawneh, 1986

Gena Taylor, 1984

 


Postdoctoral Fellows

            Eli-Anne Gjerde, Ph.D. (2002-2003); Lung endothelial calcium signaling

            Siobhan Tarpey, Ph.D. (1999-2003); Pulmonary endothelial function after heart failure

            Darryl Sawmiller, Ph.D. (1999); Pulmonary phosphodiesterase expression after

               development of heart failure

            Claire Ivey, Ph.D. (1996-1998); Pulmonary interstitial and endothelial adaptations in

               heart failure

            Bev Roy, M.D. (1992-1996); Pulmonary vascular responses to angiotensin II

Svein Åge Rodt, M.D. (1991-92); Alterations in local hemodynamics, fluid and protein

               flux, and hyaluronan washout induced by histamine and compound 48/80 in skin

DaChang Liu, M.D. (1991); Morphometric analysis of lung vasculature after the

               development of pacing-induced heart failure

Zhuodao Zhao, M.D. (1990-1992); Effects of saline loading on microvascular

               permeability and lymphatic washout of fluid, proteins, and hyaluronan  

Vijay Mathur, M.D. (1988-89); Evaluation of pulmonary hemodyamics with angiotensin

               in rabbit lung

 

 

FULL-LENGTH PUBLICATIONS

 

 1.        Riordan KK, Weiskopf RB, Townsley MI, Chadwick KR.  Oxygen-linked hydrogen ion binding of canine blood.  Pflüegers Arch. 1981; 390:99-101.

 2.            Weiskopf RB, Townsley MI, Riordan KK, Chadwick K.  Comparison of cardiopulmonary responses to graded hemorrhage during enflurane, halothane, isoflurane, and ketamine anesthesia.  Anes. Analg. 1981; 60:481-491.

 3.        Jones TA, Townsley MI, Weidner WJ.  Effects of intracranial and left atrial hypertension on lung fluid balance in sheep.  J. Appl. Physiol. 1982; 52:1324-1329.

 4.            Weiskopf RB, Townsley MI, Riordan KK, Harris D, Chadwick K.  Acid-base curve and alignment nomograms for swine blood.  J. Appl. Physiol. 1983; 54:978-983.

 5.            Townsley MI, McClure DE, Weidner WJ.  Assessment of pulmonary microvascular permeability in acutely prepared sheep.  J. Appl. Physiol. 1984; 56:857-861.

 6.        Rippe B, Townsley M, Thigpen J, Parker JC, Korthuis RJ, Taylor AE.  Effects of vascular pressure on the pulmonary microvasculature in isolated dog lungs.  J. Appl. Physiol. 1984; 57:233-239.

 7.        Parker JC, Townsley MI, Rippe B, Taylor AE, Allison RC.  Increased microvascular permeability in dog lungs due to high peak airway pressures.  J. Appl. Physiol. 1984; 57:1809-1816.

 8.            Korthuis RJ, Townsley MI, Rippe B, Taylor AE.  Estimation of isogravimetric capillary pressure by a filtration method in skeletal muscle and lung.  J. Appl. Physiol. 1984; 57:1817-1823.

 9.        Rippe B, Townsley M, Parker JC, Taylor AE.  Osmotic reflection coefficient for total plasma protein in lung microvessels.  J. Appl. Physiol. 1985; 58:436-442.

10.            Townsley MI, Korthuis RJ, Taylor AE.  Effect of arachidonic acid on the distribution of vascular resistance in the canine lung.  J. Appl. Physiol. 1985; 58:206-210.

11.            Korthuis RJ, Granger DN, Townsley MI, Taylor AE.  Autoregulation of capillary pressure and filtration rate in isolated rat hindquarters.  Am. J. Physiol. 1985; 248:H835-H842.

12.            Townsley MI, Korthuis RJ, Taylor AE.  Specific hemodynamic effects of PGE2 and PGF1" in the canine lung.  Prostagl. Leukotr. Med. 1985; 20:275-282.

13.            Korthuis RJ, Kerr CR, Townsley MI, Taylor AE.  Microvascular pressure, surface area, and permeability in isolated hindquarters of SHR.  Am. J. Physiol. 1985; 249:H498-H504.

14.            Korthuis RJ, Granger DN, Townsley MI, Taylor AE.  The role of oxygen-derived free radicals in ischemia-induced increases in canine skeletal muscle vascular permeability.  Circ. Res. 1985; 57:599-609.

15.       Taylor AE, Townsley MI, Korthuis RJ.  Macromolecule transport across the pulmonary microvessel walls.  Exp. Lung Res. 1985; 8:95-121. (INVITED)

16.            Townsley MI, Taylor GE, Korthuis RJ, Taylor AE.  Promethazine or DPPD pretreatment attenuates oleic acid-induced injury in isolated canine lungs.  J. Appl. Physiol. 1985; 59:39-46.

17.       Rippe B, Townsley MI, Taylor AE.  Effects of plasma- and cell-free perfusates on filtration coefficient of perfused isolated canine lungs.  J. Appl. Physiol. 1985; 58:1521-1527.

18.       Taylor AE, Korthuis R, Townsley M.  Use of lymphatic protein fluxes to assess vascular endothelial selectivity to macromolecules.  Prog. Appl. Microcirc. 1985; 9:100-115.

19.            Korthuis RJ, Benoit JN, Kvietys PR, Townsley MI, Taylor AE, Granger DN.  Humoral factors may mediate increased rat hindqua