3/25/05

CURRICULUM VITAE

Mary I. Townsley

PERSONAL INFORMATION

Current Position: Assistant Dean, Office of Faculty Affairs

Professor, Department of Physiology

Professional Address: Office of Faculty Affairs

College of Medicine, CSAB 170

University of South Alabama

Mobile, Alabama 36688

Phone: (251)460-7708 or 6815

FAX: (251)460-6386

Email: mtownsley@usouthal.edu

Citizenship: USA

EDUCATION

Postdoctoral training, University of South Alabama, Mobile, Alabama, 1983-1986

Ph.D., Physiology, University of California, Davis, California, 1982

B.A., Biology, Lycoming College, Williamsport, Pennsylvania, 1972

PROFESSIONAL QUALIFICATIONS

Positions Held:

Assistant Dean, Office of Faculty Affairs, 2004-present, University of South Alabama College of

Medicine, Mobile, Alabama

Director, Training Programs, Center for Lung Biology, 2002-present, University of South

Alabama College of Medicine, Mobile, Alabama

Director, Interdisciplinary Graduate Program in Basic Medical Sciences, 2001-2004, University

of South Alabama College of Medicine, Mobile, Alabama

Professor, Department of Physiology, 1995-present, University of South Alabama College of

Medicine, Mobile, Alabama

Director of Graduate Studies, 1995-1996, University of South Alabama College of Medicine,

Mobile, Alabama

Associate Professor, Department of Physiology, 1991-1995, University of South Alabama

College of Medicine, Mobile, Alabama (Promotion and tenure granted in 1991)

Assistant Professor, Department of Physiology, 1988-1991, University of South Alabama

College of Medicine, Mobile, Alabama

Assistant Professor, Department of Physiology, 1986-1988, Northeastern Ohio Universities

College of Medicine, Rootstown, Ohio

Visiting Assistant Professor, Department of Animal Physiology, 1983, University of California,

Davis, California

Professional Society Memberships:

American Physiological Society, Elected Fellow of the Cardiovascular Section, 1993

American Heart Association, Elected Fellow, AHA Council on Cardiopulmonary,

Perioperative and Critical Care, 2003

American Thoracic Society

Society for Executive Leadership in Academic Medicine

Microcirculatory Society

European Microcirculation Society

Sigma Xi

Honors:

Alpha Omega Alpha Medical Honor Society, Elected 2000

1999-2000 Class of Fellows in the Hedwig van Ameringen Executive Leadership in

Academic Medicine (ELAM) Program for Women

Travel Award for 31st IUPS, American Physiological Society, 1989

Draco Award, Microcirculation Society, 1987

Loren D. Carlsen Award in Physiology, University of California, Davis, 1983

Professional Activities:

Editorial Boards

Clinical Science, 2000-2001

Microcirculation, 1999-2002

American Journal of Physiology, Heart and Circulatory Physiology, 1997-1998

Microvascular Research, 1997-present

Ad Hoc Journal Reviews

Acta Physiologica Scandinavica

American Journal of Physiology

American Journal of Respiratory and Critical Care Medicine

Anesthesiology

Basic Research in Cardiology

Circulation Research

Hypertension

Journal of Applied Physiology

Journal of Clinical Investigation

Journal of Pharmacology and Experimental Therapeutics

Study Sections

NIH ZRG1 RES B (02), October, 2004; Chair

AHA Lung, Respiration and Resuscitation National Study Committee,

Chair, 2001-2003; Co-Chair, 1997-1998, 2000

VA Merit Review Subcommittee for Respiration, 1998-2000

Chair, Committee 4 AHA Southern Research Consortium, 1997-1998

NIH Physiological and Biological Sciences Special Emphasis Study Section, 1996

AHA Lung and Development Study Committee, 1994-1997

NIH General Medicine A Study Section, 1994

NIH Physiological Sciences Study Section, 1994

NIH Clinical Sciences Study Section; Ad Hoc 1990, 1992; Member 1992-1994

Alabama Heart Association Grant Review Board, 1991-1994

Co-Chair, 1994

Ohio Thoracic Society Grant Review Board, Ad Hoc 1987

National Committees

AHA National Research Committee, 2000-2005

AHA Steering Committee, 2004-2005

AHA Southeast Affiliate

Chair, Research Committee, 2002-2004

Vice Chair, Research Committee, 2000-2002

Board of Directors, 2002-2004

AHA Council on Cardiopulmonary and Critical Care

Vice Chair, 2003-2005

Chair, Communications Sub-committee, 2000-2003

Research Committee Representative, 2000-2005

Member, ECC Sub-committee, 2000-2002

Executive Committee, 1996-2005

Newsletter Editor, 1996-2001

Gulf Coast Physiological Society

President, 2002-2004

Microcirculatory Society

Publications Committee, 1996-1999

Executive Council, 1993-1996

American Physiological Society

Cardiovascular Section Nominating Committee (elected), 2002-2005

Women in Physiology Committee, 1996-1998

Program Committee, Cardiovascular Section, 1995-1998

Career Opportunities in Physiology Committee, 1988-1991

Mentor, NIDDK/APS Minority Fellows Program, 1988, 1989, 1997

University Committees

Conflict of Interest Committee, 2001-2004

University Research Council, 2001-2004

University Graduate Council, 2001-2004

SACS Self Study, Educational Program/Graduate Committee, 2000-2001

Chair, Subcommittee 1

Cost Accounting Standards Committee, Cost Sharing Subcommittee, 2000

University Fringe Benefits Committee, 2000-2002

Faculty Senate Salary and Benefits Committee, 1999-2001 (Chair, 2000-2001)

Faculty Grievance Committee Pool, 1999-2005

Coordinator, USA Women in Science Faculty Group, 1998-2000

Senate Handbook Committee, 1988-1989

Faculty Senate, 1988-1989; 1999-2002

College of Medicine Committees

Chair, Faculty Committee on Appointments, Promotions, and Evaluations, 2002-

2006; Member 1995-1998; 2001-2002

Chair, Research Advisory Committee, 2001-2004

Chair, LCME Self-Evaluation Subcommittee on Graduate Education in the

Science Basic to Medicine, 2001-2002

Cancer Institute: Basic/Translational Research Task Force, 2001

Internal Advisory Committee, USA Comprehensive Sickle Cell Center, 2001

Ad Hoc Committee for Development of Policy on “Standards in Conduct in the

Teacher-Learner Relationship”, 2001

Chair, Task Force on Research Organization and Performance Evaluation, 2000

Faculty Assembly, Vice-President, 1995-1997; President, 1997-1998;

Past-President, 1998-1999

Minority Affairs Advisory Committee, 1994-present

LCME Self-Evaluation Task Force, 1994-1995

Chair, Evaluation of Medical Education Subcommittee, LCME Task

Force, 1994-1995

Secretary, Basic Medical Sciences Faculty, 1992-1993

BEAR Committee, 1991-1992, 1998-2001

Committee on Standards in the Conduct of Research, 1991-1994

Basic Medical Science Student Organization, Faculty Advisor, 1991

Committee on Admissions, 1990-1993

Scholarship Subcommittee, 1990-1992

Distinguished Scientists Seminar Program, 1989-1991

Student Promotions and Evaluations, 1989-1991

Institutional Animal Care and Use, 1989-1990

Student Research, 1988-1992 (Chair 1990-1992), 1998-2001

Department of Physiology Responsibilities

Medical Physiology, Course Director, 1992-1995, 2001-2004

Course Director, Medical Physiology, Biomedical Enrichment and Recruitment

Program, 1997-2001

Graduate Coordinator, 1988-1996

College of Medicine Basic Medical Science Graduate Program Service

Director, 1995-1996, 2001-2004

Curriculum Committee, 2000-2001

Student Performance and Evaluations Committee, 1999-2000

Graduate Executive Committee

Chair, 1995-1996, 2001-2004

Member-at-large 1997-1998, 2000-2001

Graduate Admissions Committee

Chair, 1995-1996, 2001-2004

Other Service

Chair, Review Team for Department of Veterinary Physiology & Pharmacology,

Texas A&M University, Review of Doctoral Programs, 2001

Council Delegate, American Heart Association Delegate Assembly, 2001

Organizing Committee, Expanding Your Horizons, 2001-2003

Organizing Committee, Regional Science Olympiad, 2000-2002

Reviewer, American Heart Association Position Statement on “Cardiovascular

Disease in Women”, 1997

Judge, Regional Science Fair, 1997-1999

Board of Directors, American Heart Association, Southeast Affiliate, Mobile

County Division, 1995-1998

Youth Summit Advisory Committee, Alabama Cooperative Extension System,

Mobile, 2001

GRANT FUNDING

Active Awards

NIH/NHLBI (T32 HL076125): "Training in cell signaling and lung pathobiology"; 2004-2009; Total direct costs $796,231; Program director.

NIH/NHLBI (R01 HL39045): "T-lymphocyte involvement in lung ischemia-reperfusion injury”, 2003-2005; Total direct costs $400,000; Principal investigator

American Heart Association, Southeast Affiliate, Predoctoral Fellowship (Alvarez - 0315049B): “Role of P450 arachidonic acid metabolites in regulation of pulmonary endothelial cell permeability”; 2003-2005; Total direct costs $36,000; Sponsor

NIH/NHLBI (RO1 HL61955): “Heart failure-induced alterations in regulation of pulmonary endothelial permeability”, 1999-2003; Total direct costs $680,274; Principal investigator (current no cost extension)

Previous Awards

NIH/NHLBI (R01 HL39045): "Lung microcirculation with high vascular pressures", 1996-2000; Total direct costs $560,984; Principal investigator

American Heart Association Grant-in-Aid, Southeast Affiliate (9810109): “Peripheral microvascular permeability response to autocoids in heart failure: role of catecholamines and prostanoids”, 1998-2000; Total direct costs $66,071; Collaborating investigator; D. Lynn Dyess, M.D., Principal investigator

American Heart Association Grant-in-Aid, National Center (96015130): "Lung microcirculation with high vascular pressures”, 1996-1999; Total direct costs $120,000; Principal investigator (awarded but declined)

American Physiological Society, Porter Physiology Development Program; Predoctoral Fellowship for Ron McMillon, 1994-1996; Total direct costs $13,500; Faculty mentor

American Heart Association Established Investigatorship (92001990): "Lung remodeling in chronic pulmonary venous hypertension", 1992-1997; Total direct costs $265,000; Principal investigator

NIH Research Career Development Award (K04 HL02732): "Lung adaptation to chronic pulmonary hypertension", 1992-1997; Total direct costs $247,700; Principal investigator; relinquished April, 1992 to accept Established Investigatorship

NIH research grant (R01 HL39045): "Lung microcirculation with high vascular pressures", 1992-1995; Total direct costs $324,498; Principal investigator

American Heart Association Grant-in-Aid, National Center (91006760): "The pulmonary circulation in congestive heart failure", 1991-1994; Total direct costs $120,000; Principal investigator

NATO Travel grant for research collaboration : "Measurement of microvascular permeability in skin, lung, and ileum", 1989-1993; Total direct costs $15,500; Co-investigator with Dr. Rolf K. Reed, University of Bergen, Norway

ECFMG Foreign Faculty Fellowship for Dr. Vijay Devi Mathur, Professor of Physiology Kakatiya Medical College, Warangal, India, 1989-1990; Total direct costs $4,004; Co-director

NIH FIRST Award (R29 HL39045): "Lung capillary permeability with high vascular pressure", 1987-1992; Total direct costs $343,083; Principal investigator

American Heart Association, Alabama Affiliate: "Lung permeability: mechanical stress in traumatized lungs", 1986-1987; Total direct costs $15,125; Principal investigator

NIH New Investigator Award (R23 HL36332): "Lung capillary permeability with high vascular pressure", 1986-1987; Total direct costs $33,250; Principal investigator

Research Challenge (intramural award): "Contribution of blood cell components to lung injury", 1986-1987; Total direct costs $5,500; Principal investigator

Fellowship Awards --

NIH Postdoctoral Fellowship, 1984-1986

Parker B. Francis Pulmonary Fellow, 1983-1984

NIH Predoctoral Fellowship, University of California, Davis, 1979-1982

TEACHING EXPERIENCE

Biomedical Enrichment and Recruitment Program: Medical Physiology, lectures in endocrinology (6/year); 1992-2002

Graduate courses: Advanced Gastrointestinal Physiology, lectures in gut smooth muscle and motility, gastrointestinal endocrinology; Advanced Cardiovascular Physiology, lectures in smooth muscle and vascular function, control of organ blood flow, microvascular permeability, lymphatics, interstitium; Advanced Respiratory Physiology, lectures in pulmonary circulation and permeability, Computer Applications in Research, lectures and tutorials in the use of common software packages for spreadsheets, data base management, and graphics; Fundamentals in Basic Medical Sciences; Lung Biology; Lung Pathobiology; Biostatistics and Experimental Design

Medical school course: Medical Physiology, lectures in biophysics (1988-89), gastrointestinal physiology (1988-91), endocrinology (1990-2002); and neurophysiology (2002-present); 10-34 lectures/ year); also laboratories in respiratory and cardiovascular physiology

SEMINARS AND INVITED LECTURES (last 5 years)

2004 Remodeling of lung endothelial barrier function in heart failure. Pulmonary Division Research Seminar Series, University of South Alabama

TRPs and leaks in lung endothelium: A novel role for TRPV4, a vanilloid receptor TRP channel. Cell Signaling Seminar Series, University of South Alabama

TRPV4 - The "other" TRP channel. Center for Lung Biology Research in Progress, University of South Alabama.

Remodeling of lung endothelial barrier function in heart failure – A role for EETs and SOC? Department of Physiology, LSU Health Sciences Center, New Orleans

2003 Remodeling of lung endothelial barrier function in heart failure – A role for EETs and SOC? Cardiovascular Center, Medical College of Wisconsin

Pulmonary interstitium. Grand Rounds, Department of Surgery, University of South Alabama

Pressure tactics: The lung and pulmonary hypertension. The Odyssey Program, University of South Alabama

2002 Remodeling of alveolar-capillary barrier in chronic pulmonary venous hypertension. ATS Symposium: Mechanical factors in postnatal lung growth and remodeling

2001 Altered regulation of pulmonary endothelial permeability in chronic heart failure: A role for P450 epoxygenases?; Pulmonary Division, Northwestern University School of Medicine

The lung in heart failure: a tale of form and function. Department of Physiology, University of South Alabama

Functional and structural lung remodeling in congestive heart failure, American Thoracic Society Assembly Workshop on Mechanisms and Limits of Lung Growth, San Francisco

Pulmonary adaptations in chronic heart failure, Heart Failure Division, Medtronic, Inc., Minneapolis

INVOLVEMENT IN TRAINING

Undergraduate research

Emile Addison (USA), Dept. of Biology Honors Program, 2005

Brandy Merritt (USA), 2002

Beth Phillips (Spring Hill College), 2001 and 2002

Michael Stallworth (USA), 1999

Anne Barañano (Haverford College), 1999

Darlene Moyer (Lycoming College), 1999

Shari Leuwerke (St. Olaf’s College), 1998

James Lakey (USA), 1996

Darren Waters (USA), 1994

Marirose Jordan (USA), 1993

Rupa Kothandapani (USA), 1992

Master's degree in Biology

Margery Halstead (M.S., 1993); Pulmonary vascular responses to ACh and bradykinin in

pacing-induced heart failure

Mentor, Ph.D. in Physiology

Diego Alvarez (2001-projected completion spring 2005); Alterations in pulmonary

endothelial permeability after heart failure

Ronald McMillon (Ph.D., 1998); Reactivity of canine bronchial vasculature in normal

lung compared to that following the development of heart failure

Allen Lee (1994-1995); Mechanisms for attenuation of alveolar edema with chronic

pulmonary venous hypertension

Service on other Ph.D. Committees

Patti Sadowsky (Pharmacology); Epitope mapping of monoclonal antibodies to the

FK506 binding immunophilin FKBP51

Qining Qin (Physiology, Ph.D. 2004); Signal transduction pathways in myocardial

preconditioning

Wesley Denny (Pharmacology, Ph.D. 2003); Role of an FK506 binding immunophilin in

glucocorticoid resistance of the squirrel monkey

Kathy Ault-Ziel (Pharmacology, Ph.D., 2002); Hypoxia and matrix remodeling

Natalie Norwood (Pharmacology, Ph.D., 2001); Gating of Trp-1 by F-actin cytoskeleton

David Killilea (Pharmacology, Ph.D., 2000); Oxidant DNA damage and signal

transduction in lung tissue

Cherry Ballard (Pharmacology, Ph.D., 1998); Signal transduction mechanism for the

stimulation of the cardiac Na⁺-Ca²⁺ exchanger by insulin

Peter Wilson (Physiology, Ph.D., 1998); Mechanisms of pulmonary vascular tone

regulation by nitric oxide in isolated rat lungs

Ling Zhao (Pharmacology, Ph.D. , 1997); Molecular characteristics of

phosphodiesterases in pulmonary microvascular endothelium

Hafeez Diwan (Pharmacology, Ph.D., 1997); Mechanism of regulation of rat pulmonary

microvascular endothelial cell permeability by cGMP

Tim Moore (Physiology, Ph.D., 1996); Role of cyclic nucleotides and adhesion

molecules in lung ischemia reperfusion injury

Todd Engerson ( Biochemistry, Ph.D., 1991); Role of xanthine oxidase in liver ischemia

reperfusion injury

Keith Adkins (Physiology, Ph.D., 1991); Lung ischemia reperfusion injury

Medical Student Research (Summer Research Program unless noted)

William Porr, 2003

Michael Sprague, 2001

Deborah Weiss, 2000

Jimmie Lakey, 1999

Chris Heck, 1998

Leslie Hunter, 1997 and 1 month senior elective, 1999

Marirose Jordan, 1995

Tu Tran, 1993

Ken Snell, 1992

Morgan Smith, 5 months, senior elective, 1989

Sam Bartle, 12 months, 1988-89

Esther Lim, 1987

Tuomah Sahawneh, 1986

Gena Taylor, 1984

Postdoctoral Fellows

Eli-Anne Gjerde, Ph.D. (2002-2003); Lung endothelial calcium signaling

Siobhan Tarpey, Ph.D. (1999-2003); Pulmonary endothelial function after heart failure

Darryl Sawmiller, Ph.D. (1999); Pulmonary phosphodiesterase expression after

development of heart failure

Claire Ivey, Ph.D. (1996-1998); Pulmonary interstitial and endothelial adaptations in

heart failure

Bev Roy, M.D. (1992-1996); Pulmonary vascular responses to angiotensin II

Svein Åge Rodt, M.D. (1991-92); Alterations in local hemodynamics, fluid and protein

flux, and hyaluronan washout induced by histamine and compound 48/80 in skin

DaChang Liu, M.D. (1991); Morphometric analysis of lung vasculature after the

development of pacing-induced heart failure

Zhuodao Zhao, M.D. (1990-1992); Effects of saline loading on microvascular

permeability and lymphatic washout of fluid, proteins, and hyaluronan

Vijay Mathur, M.D. (1988-89); Evaluation of pulmonary hemodyamics with angiotensin

in rabbit lung

FULL-LENGTH PUBLICATIONS

1. Riordan KK, Weiskopf RB, Townsley MI, Chadwick KR. Oxygen-linked hydrogen ion binding of canine blood. Pflüegers Arch. 1981; 390:99-101.

2. Weiskopf RB, Townsley MI, Riordan KK, Chadwick K. Comparison of cardiopulmonary responses to graded hemorrhage during enflurane, halothane, isoflurane, and ketamine anesthesia. Anes. Analg. 1981; 60:481-491.

3. Jones TA, Townsley MI, Weidner WJ. Effects of intracranial and left atrial hypertension on lung fluid balance in sheep. J. Appl. Physiol. 1982; 52:1324-1329.

4. Weiskopf RB, Townsley MI, Riordan KK, Harris D, Chadwick K. Acid-base curve and alignment nomograms for swine blood. J. Appl. Physiol. 1983; 54:978-983.

5. Townsley MI, McClure DE, Weidner WJ. Assessment of pulmonary microvascular permeability in acutely prepared sheep. J. Appl. Physiol. 1984; 56:857-861.

6. Rippe B, Townsley M, Thigpen J, Parker JC, Korthuis RJ, Taylor AE. Effects of vascular pressure on the pulmonary microvasculature in isolated dog lungs. J. Appl. Physiol. 1984; 57:233-239.

7. Parker JC, Townsley MI, Rippe B, Taylor AE, Allison RC. Increased microvascular permeability in dog lungs due to high peak airway pressures. J. Appl. Physiol. 1984; 57:1809-1816.

8. Korthuis RJ, Townsley MI, Rippe B, Taylor AE. Estimation of isogravimetric capillary pressure by a filtration method in skeletal muscle and lung. J. Appl. Physiol. 1984; 57:1817-1823.

9. Rippe B, Townsley M, Parker JC, Taylor AE. Osmotic reflection coefficient for total plasma protein in lung microvessels. J. Appl. Physiol. 1985; 58:436-442.

10. Townsley MI, Korthuis RJ, Taylor AE. Effect of arachidonic acid on the distribution of vascular resistance in the canine lung. J. Appl. Physiol. 1985; 58:206-210.

11. Korthuis RJ, Granger DN, Townsley MI, Taylor AE. Autoregulation of capillary pressure and filtration rate in isolated rat hindquarters. Am. J. Physiol. 1985; 248:H835-H842.

12. Townsley MI, Korthuis RJ, Taylor AE. Specific hemodynamic effects of PGE₂ and PGF_1" in the canine lung. Prostagl. Leukotr. Med. 1985; 20:275-282.

13. Korthuis RJ, Kerr CR, Townsley MI, Taylor AE. Microvascular pressure, surface area, and permeability in isolated hindquarters of SHR. Am. J. Physiol. 1985; 249:H498-H504.

14. Korthuis RJ, Granger DN, Townsley MI, Taylor AE. The role of oxygen-derived free radicals in ischemia-induced increases in canine skeletal muscle vascular permeability. Circ. Res. 1985; 57:599-609.

15. Taylor AE, Townsley MI, Korthuis RJ. Macromolecule transport across the pulmonary microvessel walls. Exp. Lung Res. 1985; 8:95-121. (INVITED)

16. Townsley MI, Taylor GE, Korthuis RJ, Taylor AE. Promethazine or DPPD pretreatment attenuates oleic acid-induced injury in isolated canine lungs. J. Appl. Physiol. 1985; 59:39-46.

17. Rippe B, Townsley MI, Taylor AE. Effects of plasma- and cell-free perfusates on filtration coefficient of perfused isolated canine lungs. J. Appl. Physiol. 1985; 58:1521-1527.

18. Taylor AE, Korthuis R, Townsley M. Use of lymphatic protein fluxes to assess vascular endothelial selectivity to macromolecules. Prog. Appl. Microcirc. 1985; 9:100-115.

19. Korthuis RJ, Benoit JN, Kvietys PR, Townsley MI, Taylor AE, Granger DN. Humoral factors may mediate increased rat hindquarter blood flow in portal hypertension. Am. J. Physiol. 1985; 249:H827-H833.

20. Townsley MI, Korthuis RJ, Rippe B, Parker JC, Taylor AE. Validation of double vascular occlusion method for P_c,i in lung and skeletal muscle. J. Appl. Physiol. 1986; 61:127-132.

21. Martin D, Korthuis RJ, Perry M, Townsley MI, Taylor AE. Oxygen radical-mediated lung damage associated with "-napthylthiourea. Acta Physiol. Scand. 1986; 126 (Suppl. 548):119-125.

22. Allison RC, Marble KT, Hernandez EM, Townsley MI, Taylor AE. Attenuation of permeability lung injury after phorbol myristate acetate by verapamil and OKY-046. Am. Rev. Resp. Dis. 1986; 134:93-100.

23. Rippe B, Parker JC, Townsley MI, Mortillaro NA, Taylor AE. Segmental vascular resistances and compliances in dog lung. J. Appl. Physiol. 1987; 62:1206-1215.

24. Townsley MI, Parker JC, Korthuis RJ, Taylor AE. Alterations in hemodynamics and K_f,c during lung mass resection. J. Appl. Physiol. 1987; 63:2460-2466.

25. Weidner WJ, Jones TA, Townsley MI, DeFouw DO. Ultrastructural analysis of sheep lungs after increased intracranial pressure and development of pulmonary edema. Microcirc. Endoth. Lymphatics 1987; 3:397-410.

26. Taylor AE, Townsley MI. Evaluation of the Starling fluid flux equation. News in Physiol. Sci. 1987; 2:48-52. (INVITED)

27. Townsley MI, Parker JC, Longenecker GL, Perry ML, Pitt RM, Taylor AE. Pulmonary embolism: analysis of endothelial pore sizes in canine lung. Am. J. Physiol. 1988; 255:H1075-H1083.

28. Parker JC, Townsley MI, Cartledge JT. Lung edema increases transvascular filtration rate but not filtration coefficient. J. Appl. Physiol. 1989; 66:1553-1560.

29. Reed RK, Townsley MI, Taylor AE. Estimation of capillary reflection coefficient and unique PS products in dog paw. Am. J. Physiol. 1989; 257:H1037-H1041.

30. Townsley MI, Barman SA, Taylor AE. Pulmonary embolism: emboli and fibrinolysis inhibition in isolated canine lungs. Am. J. Physiol. 1990; 258:H754-H758.

31. Shibamoto T, Parker JC, Taylor AE, Townsley MI. Derecruitment of filtration surface area in paraquat-injured dog lungs. J. Appl. Physiol. 1990; 68:1581-1589.

32. Negrini D, Townsley MI, Taylor AE. Hydraulic conductivity of canine parietal pleura in vivo. J. Appl. Physiol. 1990; 69:438-442.

33. Townsley MI, Lim EH, Sahawneh TM, Song W. Interaction of chemical and high vascular pressure injury in isolated canine lung. J. Appl. Physiol. 1990; 69:1657-1664.

34. Townsley MI, Negrini D, Ardell JL. Regional blood flow to canine parietal pleura and internal intercostal muscle. J. Appl. Physiol. 1991; 70:97-102.

35. Reed RK, Townsley MI, Korthuis RJ, Taylor AE. Analysis of lymphatic protein flux data. V. Unique PS products and F_d's at low lymph flows. Am. J. Physiol. 1991; 261:H728-H740.

36. Ishibashi M, Reed RK, Townsley MI, Parker JC, Taylor AE. Albumin transport across pulmonary capillary-interstitial barrier in anesthetized dogs. J. Appl. Physiol. 1991; 70:2104-2110.

37. Ferrara JJ, Reed RK, Dyess DL, Townsley MI, Onarheim H, Laurent TC, Taylor AE. Increased hyaluronan flux from skin following burn injury. J. Surg. Res. 1991; 50:240-244.

38. Townsley MI, Smith SM, Reed RK, Pitts VH, Taylor AE. Ileal microvascular permeability: a comparison of PS and F_d using lymphatic and isotopic protein clearances. Am. J. Physiol. 1992; 262:G572-G580.

39. Reed RK, Townsley MI, Laurent TC, Taylor AE. Hyaluronan flux from cat intestine: changes with lymph flow. Am. J. Physiol. 1992; 262:H457-H462.

40. Dyess DL, Ardell JL, Townsley MI, Taylor AE, Ferrara JJ. Effects of hypertonic saline and dextran 70 resuscitation on microvascular permeability after burn. Am. J. Physiol. 1992; 262:H1832-H1837.

41. Reed RK, Townsley MI, Korthuis R, Taylor AE. Letter to the Editor. Am. J. Physiol. 1992; 263:H1972-H1973.

42. Reed RK, Townsley MI, Smith SM, Laurent TC, Taylor AE. Increased lymphatic flux of hyaluronan from cat intestine during fat absorption. Am. J. Physiol. 1992; 263:G6-G11.

43. Laurent TC, Alston-Smith J, Allen SJ, Asplund T, Berg S, Dahl IMS, Dahl LB, Edelstam GAB, Forsberg N, Engström-Laurent A, Fraser JRE, Gustafson S, Heldin P, Henriksen JH, Johnsson H, Laurent C, Laurent UBG, Lebel L, Lilja K, Lindqvist U, McCourt PAG, Pertoft H, Reed RK, Rodén L, Smedsröd B, Tengblad A, Townsley MI, Wells A, Wikström T, Ytterberg D. Turnover of hyaluronan. In: Proceedings of the 2nd Joint Meeting on Carbohydrates, Grado, Italy. 1992; p. 11-14.

44. Reed RK, Ishibashi M, Townsley MI, Parker JC, Taylor AE. Blood-to-tissue clearance vs. lymph analysis in determining capillary transport characteristics for albumin in skin. Am. J. Physiol. 1993; 264:H1394-H1401.

45. Ferrara JJ, Dyess DL, Collins JN, Fish JM, Ardell JL, Townsley MI, Taylor AE, Flint LM. Effects of pentafraction administration on microvascular permeability alterations induced by graded thermal injury. Surgery 1994; 115:182-189.

46. Collins JN, Dyess DL, Ardell JL, Townsley MI, Taylor AE, Ferrara JJ. The effects of albumin administration on microvascular permeability at the site of burn injury. J. Trauma 1994; 36:27-33.

47. Reed RK, Townsley MI, Zhao Z, Ishibashi M, Laurent TC, Taylor AE. Lymphatic hyaluronan flux from skin increases during increased lymph flow induced by intravenous saline loading. Int. J. Microcirc. 1994; 14:56-61.

48. Negrini, D, Venturoli D, Townsley MI, Reed RK. Permeability of the parietal pleura to liquid and proteins. J. Appl. Physiol. 1994; 76:627-633.

49. Townsley MI, Pitts VH, Ardell JL, Zhao Z, Johnson WH Jr. Altered pulmonary microvascular reactivity to norepinephrine in canine pacing-induced heart failure. Circ. Res. 1994; 75:347-356.

50. Ferrara JJ, Dyess DL, Collins JN, Fish JM, Markert AJ, Ardell JL, Townsley MI, Flint LM, Taylor AE. Effects of graded thermal injury on microvascular permeability at the site of injury. J. Surg. Res. 1994; 57:420-426.

51. Rodt SÅ, Reed RK, Townsley MI. Increased hyaluronan flux in canine paw lymph induced by histamine and the histamine-releasing agent C48-80. Int. J. Microcirc. 1994; 14:212-217.

52. Townsley MI, Reed RK, Ishibashi M, Parker JC, Laurent TC, Taylor AE. Hyaluronan efflux from canine lung: effects of increased hydrostatic pressure and saline loading. Am. J. Resp. Crit. Care Med. 1994; 150:1605-1611.

53. Townsley MI, Fu Z, Mathieu-Costello O, West JB. Pulmonary microvascular permeability: responses to high vascular pressure after induction of pacing-induced heart failure in dogs. Circ. Res. 1995; 77:317-325.

54. Rizzo A, Taylor AE, Townsley MI, Logsdon P, Khimenko P, Fletcher JR. Platelet-activating factor increases vascular resistance in rat hindquarters by thromboxane A₂. Am. J. Physiol. 1995; 268:H1954-H1958.

55. Townsley MI, McMillon RK, Lee AK. Regulation of tissue oxygenation. Sem. Resp. Crit. Care Med. 1995; 16:361-371. (INVITED)

56. Townsley MI, Erlanson-Albertsson C, Olsson A, Reed RK. Enterostatin flux in cat intestinal lymph: relation to lymph flow, hyaluronan, and fat absorption. Am. J. Physiol. 1996; 271:G714-G721.

57. Roy B, Townsley MI. Pulmonary vascular responses to angiotensin II in canine pacing-induced heart failure. Am. J. Physiol. 1996; 271:H222-H227.

58. Taylor AE, Moore TM, Townsley MI. Evaluation of endothelial barrier damage in lungs. Pathophysiology 1998; 5:85-90

59. Ivey CL, Roy BJ, Townsley MI. Ablation of lung endothelial injury after pacing-induced heart failure is related to alterations in calcium signaling. Am. J. Physiol. 1998; 275:H844-H851.

60. Ivey CL, Stephenson AH, Townsley MI. Involvement of cytochrome P450 enzyme activity in the control of microvascular permeability in canine lung. Am. J. Physiol. 1998; 275:L756-L763.

61. Parker JC, Townsley MI, Stevens T. Calcium dependence of mechanical injury to lung capillaries. Letter to the Editor. J. Appl. Physiol. 1999; 86:775-776.

62. McMillon RK, Townsley MI. "-Adrenergic vasoreactivity of canine intrapulmonary bronchial arteries in pacing-induced heart failure. Am. J. Physiol. 1999; 277:H1392-H1402.

63. Townsley MI, Snell KS, Ivey CL, Culberson DE, Liu D, Reed RK, Mathieu-Costello O. Remodeling of interstitium but not extra-alveolar resistance vessels in canine pacing-induced heart failure. J. Appl. Physiol. 1999; 87:1823-1830.

64. Zhu D, Bousamra M, Zeldin DC, Falck JR, Townsley MI, Harder DR, Roman RJ, Jacobs ER. Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries. Am. J. Physiol. 2000; 278:L335-L343.

65. Dyess DL, Collins JN, Ardell JL, Townsley MI, Taylor AE, Ferrara JJ. Modulation of microvascular permeability after burn injury by 21-aminosteroids. J. Burn Care Rehabil. 2000; 21:406-413.

66. Dyess DL, Hunter JL, Lakey JR, Moyer D, Dougherty FG, Townsley MI. Attenuation of histamine-induced endothelial permeability responses after pacing-induced heart failure: role for endogenous catecholamines. Microcirculation 2000;7:307-316.

67. Townsley MI. Successful grantsmanship: Navigating the AHA granting process. Newsletter of the Council on Cardiopulmonary and Critical Care 2001; Fall. (INVITED)

68. Tarpey SB, Sawmiller DR, Kelly CI, Thompson WJ, Townsley MI. Phosphodiesterase 3 (PDE 3) activity is reduced in dog lung following pacing-induced heart failure. Am. J. Physiol. Lung Cell Mol. Physiol. 2003; 283: L766-L773.

69. Trout L, Townsley MI, Bowden AL, Ballard ST. Disruptive effects of anion secretion inhibitors on airway mucus morphology in isolated perfused pig lungs. J. Physiol. 2003; 549: 845-853.

70. Dougherty FC, Donovan FM, Townsley MI. Harmonic analysis of perfusion pumps. J. Biomech. Eng. 2003; 125: 814-822.

71. Parker JC, Townsley MI. Evaluation of lung injury in rats and mice. Am. J. Physiol. Lung Cell Mol. Physiol 2004; 286: L231-L246. INVITED REVIEW

72. Alvarez DF, Gjerde EB, Townsley MI. Role of EETs in regulation of endothelial permeability in rat lung. Am. J. Physiol. Lung Cell Mol. Physiol. 2004; 286: L445-L451.

73. Hsia C, Berberich MA, Driscoll B, Laubach VE, Lillehei CW, Massaro DJ, Perkett EA, Pierce RA, Rannels DE, Ryan RM, Tepper RS, Townsley MI, Veness-Meehan KA, Wang N, Warburton D. ATS Document: Mechanisms and limits of induced postnatal lung growth. Am. J. Respir. Crit. Care Med. 2004; 170: 319-343.

74. Wu S, Cioffi EA, Alvarez D, Sayner SL, Chen H, Cioffi DL, King J, Creighton JR, Townsley M, Goodman SR, Stevens T. Essential role of a Ca²⁺ selective, store operated current (I_SOC) in endothelial cell permeability. Determinants of the vascular leak site. Circ. Res. 2005; in press.

75. Alvarez DF, King JA, Townsley MI. Downregulation of TRPC1 and TRPC4 contributes to resistance against store depletion-induced endothelial injury in rat lung after chronic heart failure. Circ. Res. 2004; submitted.

BOOK CHAPTERS

1. Taylor AE, Rippe B, Townsley M, Korthuis R, Parker JC. Interstitial lung tissue fluid resistance. In: Frontiers in Physiological Research. Garlick DG, Korner PI, eds. Canberra: Australian Academy of Sciences. 1984; p. 147-154.

2. Taylor AE, Martin D, Townsley MI. Oxygen radicals and pulmonary edema. In: The pulmonary circulation and acute lung injury. Said SI, ed. Mount Kisco, NY: Futura Publishing, 1985; p. 307-320.

3. Taylor AE, Cope DK, Allison RC, Townsley MI, Holloway H. Estimation of pulmonary capillary pressure using Swan-Ganz catheters. In: Update in intensive care and emergency medicine. Vincent JL, ed. Berlin: Springer-Verlag, 1985; p. 127-132.

4. Townsley MI, Taylor AE. Role of oxygen radicals in free fatty acid-induced lung injury. In: Physiology of oxygen radicals. Taylor AE, Matalon S, Ward P, eds. Bethesda: American Physiological Society, 1986; p.169-186.

5. Taylor AE, Townsley MI. Assessment of oxygen radical tissue damage. In: Physiology of oxygen radicals. Taylor AE, Matalon S, Ward P, eds. Bethesda: American Physiological Society, 1986; p.19-38.

6. Townsley MI, Taylor AE. Involvement of oxygen radicals in pulmonary edema. In: Handbook of free radicals and antioxidants in biomedicine, Vol. 1. Miquel J, Quintanilha AT, Weber H, Eds. Boca Raton: CRC Press, Inc., 1989; p. 297-314.

7. Townsley MI, Lee AK, McMillon RK, Roy BJ. Pulmonary microvascular adaptations to heart failure and pulmonary venous hypertension. In: The pathophysiology of tachycardia induced heart failure. Spinale FG, Ed. Mount Kisco, NY: Futura Publishing Co. 1996; 173-192.

8. Townsley MI, Neal C, Michel CC. High vascular pressure injury. In: Connective Tissue Biology: Integration and Reductionism. Reed RK, Rubin K, Eds., Portland Press, London, 1998, pp. 207-220.

9. Townsley MI. Hydrostatic pulmonary edema. In: Pulmonary Edema. Matthay M, Ingbar D, Eds., Marcel Dekker, New York, 1998, pp. 163-202.

ABSTRACTS

1. Townsley MI, Brinks HA, Weiskopf RB. Measurement of enflurane and isoflurane by mass spectroscopy. Abstracts of Scientific Papers, American Society of Anesthesiologists. 1978; p. 289.

2. Weiskopf RB, Moores WY, Riordan KK, Townsley MI, Crum JD, Willford D, Dembitsky WB. Left ventricular dynamics: A comparison of morphine and halothane during normoxia. Abstracts of Scientific Papers, American Society of Anesthesiologists. 1978; p. 321.

3. Weiskopf RB, Moores WY, Riordan KK, Townsley MI, Willford D, Dembitsky WB, Chadwick K, Crum J. Depression of swine left ventricular function by halothane. Clin. Res. 1978; 26:98A.

4. Townsley MI, Weidner WJ. Influence of adenosine triphosphate on lung fluid balance. Physiologist 1981; 24:17.

5. Townsley MI, Weidner WJ. Effects of sequential recruitment of pulmonary microvascular surface area on lung fluid balance. Physiologist 1982; 25:206.

6. Townsley MI, Weidner WJ. Influence of histamine on fluid balance in the prerecruited lung. Fed. Proc. 1982; 41:1502.

7. Weidner WJ, McClure, Newton SG, Townsley MI. Influence of aspirin on fluid balance in the prerecruited lung. Fed. Proc. 1983; 42:1273.

8. Rippe B, Parker JC, Thigpen J, Korthuis RJ, Townsley M, Taylor AE. Effect of high vascular pressures on capillary filtration coefficient (K_f,c) in the lung. Microvas. Res. 1984; 27:260.

9. Townsley MI, Rippe B, Taylor AE. The effect of marked, brief increases in pulmonary microvascular pressures on permeability in the isolated canine lung. Microvasc. Res. 1984; 27:267.

10. Parker JC, Rippe B, Townsley MI, Taylor AE. Effect of peak airway pressure (PAW) on microvascular permeability in the lung. Fed. Proc. 1984; 43:513.

11. Townsley MI, Taylor AE. The effects of arachidonic acid on pulmonary capillary pressure and resistance distribution in the canine lung. Fed. Proc. 1984; 43:922.

12. Townsley MI, Korthuis RJ, Taylor AE. The effect of oleic acid on microvascular permeability in isolated canine lung lobes. Int. J. Microcirc. 1984; 3:347.

13. Taylor AE, Townsley MI, Korthuis R. The measurement of endothelial permeability to macromolecules relative to charge and molecular size using lymphatic analyses. Int. J. Microcirc. 1984; 3:417.

14. Rippe B, Parker JC, Townsley M, Korthuis RJ, Taylor AE. High left atrial pressures, marked plasma protein reductions and oleic acid or ANTU infusions cause increases in pulmonary hydraulic conductivity. Int. J. Microcirc. 1984; 3:302.

15. Townsley MI, Parker JC, Korthuis RJ, Taylor AE. Effects of decreases in lung mass on the pulmonary capillary filtration coefficient (K_f,c) and hemodynamics. Microvas. Res. 1985; 29:254-255.

16. Townsley MI, Taylor GE, Korthuis RJ, Taylor AE. Attenuation of oleic acid injury with promethazine (P) and N,N'-diphenyl-p-phenylenediamine (DPPD). Fed. Proc. 1985; 44:916.

17. Townsley M, Korthuis R, Parker J, Taylor A. Effects of methylprednisolone on pulmonary vascular resistance and capillary pressure in isolated lungs during active vasoconstriction. Int. J. Microcirc. 1985; 4:214.

18. Townsley MI, Taylor AE. The effects of zymosan activated plasma (ZAP) on the canine lung. Physiologist 1985; 28:347.

19. Parker JC, Cartledge JA, Taylor AE, Townsley MI. Hydraulic conductivity of subcutaneous and pulmonary interstitium during edema. Physiologist 1985; 28:349.

20. Townsley MI, Taylor AE. Osmotic reflection coefficients (F) after glass bead microemboli in canine lungs. Fed. Proc. 1986; 45:284.

21. Taylor AE, Townsley MI, Perry M. Estimation of macromolecule permeability surface-area product. Fed. Proc. 1986; 45:1143.

22. Allison RC, Marble KT, Hernandez EM, Townsley MI, Taylor AE. Effect of verapamil and OKY-046 on phorbol myristate acetate (PMA)-induced lung injury. Fed. Proc. 1986; 45:401.

23. Townsley MI, Perry M, Taylor AE. Effect of complement fragments on permeability in the isolated sheep lung. Proc. Int. Union Physiol. Sci. 1986; 16:358.

24. Twohig B, Taylor AE, Townsley MI. Influence of fibrinolysis inhibition in glass bead embolization in canine lung. Physiologist 1986; 29:106.

25. Perry ML, Townsley MI, Taylor AE. Effects of phorbol myristate acetate (PMA) in isolated rat lungs. Physiologist 1986; 29:107.

26. Nibler B, Townsley MI, Coker P, Parker JC. Pulmonary microvascular permeability and edema "safety factor" after saline lavage. Physiologist 1986; 29:104.

27. Townsley MI. Osmotic reflection coefficient (F_d): filtration volume technique for protein fractions in injured lungs. Fed. Proc. 1987; 46:1543.

28. Townsley MI, Sahawneh TM, Taylor AE. Response to high vascular pressure (HiP_v) after airway acid instillation (AAI) in isolated canine lungs. Fed. Proc. 1987; 46:1101.

29. Townsley MI, Lim EH. Effect of high vascular pressure (HiP_v) after oleic acid injury (OA) in isolated canine lungs. FASEB J. 1988; 2:A1705.

30. Townsley MI, Lim EH. Effect of high venous pressures (HiP_v) in canine lungs. FASEB J. 1988; 2:A1881.

31. Townsley MI, Negrini D, Ardell JL. Parietal pleura and internal intercostal muscle blood flow in the dog. FASEB J. 1989; 3:A694.

32. Townsley MI, Bartle ST, Senteno EC, Barnard JW. Evaluation of leak sites associated with high vascular pressure in the dog lung using vascular corrosion casting. FASEB J. 1989; 3:A1403.

33. Barman SA, Ardell JL, Townsley MI, Beisel B, Taylor AE. The effect of pressure gradients on canine airway blood flow. FASEB J. 1989; 3:A569.

34. Parker JC, Townsley MI, Hernandez LA, Twohig B, Perry M, Adkins K, Taylor AE. Allometric study of pulmonary capillary filtration coefficient (K_f,c). FASEB J. 1989; 3:A1141.

35. Adkins WK, Townsley MI, Parker JC. Estimation of the reflection coefficient in isolated rabbit lungs. FASEB J. 1989; 3:A1141.

36. Reed RK, Townsley MI, Taylor AE. Permeability-surface area (PS) product and capillary reflection coefficient (F) for total protein determined from unique properties of the Peclet number. FASEB J. 1989; 3:A269.

37. Negrini D, Townsley MI, Taylor AE. Hydraulic conductivity of the parietal pleura in dogs. FASEB J. 1989; 3:A694.

38. Townsley MI, Reed RK, Taylor AE. Unique permeability-surface area (PS) products and reflection coefficients (F) in the feline small intestine. Physiologist 1989; 32:157.

39. Ishibashi M, Reed RK, Townsley MI, Parker JC, Taylor AE. Permeability-surface area product (PS) and reflection coefficient (F) at maximal protein diffusion in pulmonary capillaries. Physiologist 1989; 32:201.

40. Townsley MI, Smith SM, Reed RK, Taylor AE. Albumin permeability surface area (PS) products and reflection coefficients (F) in feline ileum. FASEB J. 1990; 4:A1273.

41. Ishibashi M, Reed RK, Townsley MI, Parker JC, Taylor AE. Capillary-interstitial barrier properties for albumin in the canine lung. FASEB J. 1990; 4:A589.

42. Mathur V, Townsley MI, Adkins WK, Taylor AE. Arteriolar resistance increased by angiotensin II (AII) decreases exchange surface area in rabbit lungs. FASEB J. 1990; 4:A970.

43. Collins JN, Ferrara JJ, Dyess DL, Ardell JL, Townsley MI, Taylor AE. The effects of albumin resuscitation on microvascular permeability at the site of burn injury. FASEB J. 1990; 4:591.

44. Dyess DL, Ferrara JJ, Ardell JL, Townsley MI, Taylor AE. Microvascular permeability alterations at the site of burn injury: effects of hypertonic fluid resuscitation. FASEB J. 1990; 4:A237.

45. Reed RK, Ferrara JJ, Dyess DL, Onarheim H, Townsley MI, Laurent TC, Taylor AE. Increased hyaluronan (HA) flux from skin in burn injury. FASEB J. 1990; 4:A591.

46. Townsley MI, Reed RK, Smith SM, Taylor AE. Immunoglobulin G (IgG) permeability surface area (PS) products and reflection coefficients (F) in feline ileum. Int. J. Microcirc. 1990; 9:203.

47. Taylor AE, Townsley MI, Reed RK. Mechanisms of transcapillary protein exchange. Int. J. Microcirc. 1990; 9:68.

48. Reed RK, Townsley MI, Taylor AE. Unique permeability surface-area (PS) products and capillary reflection coefficients (F_d) in the dog paw determined at near control. Int. J. Microcirc. 1990; 9:201.

49. Reed RK, Townsley MI, Smith SM, Laurent TC, Taylor AE. Hyaluronan (HYA) concentration in feline intestinal lymph at increased transvascular and interstitial fluid flux. Physiologist 1990; 33:A100.

50. Townsley MI, Ardell JL, Johnson WH Jr. Congestive heart failure alters pulmonary vascular reactivity, but not permeability. FASEB J. 1991; 5:A406.

51. Zhao Z, Townsley MI. Effect of saline volume loading and increased pressure on lymph protein and fluid fluxes in dog paw. FASEB J. 1991; 5:A1752.

52. Johnson WH Jr, Artman M, Townsley MI, Ardell JL. Myocardial beta-adrenergic alterations in pacing-induced congestive heart failure. FASEB J. 1991; 5:A1496.

53. Collins J, Dyess D, Ardell J, Townsley M, Taylor A, Ferrara J. Albumin's effects on microvascular permeability in burn injury. FASEB J. 1991; 5:A1752.

54. Reed RK, Townsley MI, Taylor AE. Increased hyaluronan (HYA) flux in intestinal lymph during fat absorption. FASEB J. 1991; 5:A1138.

55. Collins J, Dyess D, Townsley M, Ardell J, Ferrara J. The effects of 21-aminosteroids on capillary permeability at the site of burn injury. The Society of University Surgeon's Residents' Program. 1991.

56. Zhao Z, Ishibashi M, Townsley MI. Effect of saline loading and increased pressure on lymph protein and fluid fluxes in dog lung. Proc. 5th World Cong. Microcirc. 1991; p. 128.

57. Liu DC, Ardell JL, Johnson WH Jr, Townsley MI. Pulmonary microvascular remodeling in congestive heart failure (CHF). Proc. 5th World Cong. Microcirc. 1991; p. 68.

58. Townsley MI, Reed RK, Ishibashi M, Taylor AE. Effects of increased vascular pressures on lymph and plasma hyaluronan in the canine lung. Proc. 5th World Cong. Microcirc. 1991; p. 112.

59. Reed RK, Ishibashi M, Townsley MI, Parker JC, Taylor AE. Comparison of blood-to-tissue clearance of tracer and endogenous albumin fluxes to determine PS-product and reflection coefficient (F_d). Proc. 5th World Cong. Microcirc. 1991; p. 90.

60. Collins J, Dyess D, Townsley M, Ardell J, Taylor A. Graded thermal injury effects on capillary permeability. Assoc. Acad. Surgery 1991; p. 63.

61. Zhao Z, Liu D, Ardell JL, Townsley MI. Lung blood flow distribution in congestive heart failure. FASEB J. 1992; 6:A1243.

62. Reed RK, Zhao Z, Townsley MI, Taylor AE. Prenodal hyaluronan (HYA) flux from skin during saline loading. FASEB J. 1992; 6:A2083.

63. Townsley MI, Ardell JL, Pitts VH. Altered pulmonary "-adrenergic responses in congestive heart failure (CHF). FASEB J. 1992; 6:A2086.

64. Ardell JL, McGirt AS, Knickrehm J, Rahman Z, Artman M, Townsley MI. Cardiac responses elicited by autonomic and $-adrenergic stimulation in congestive heart failure. FASEB J. 1992; 6:A1530.

65. Rodt SÅ, Reed RK, Taylor AE, Townsley MI. Changes in local hemodynamics, fluid and protein flux induced by compound 48/80. FASEB J. 1992; 6:A2037.

66. Ferrara JJ, Fish FM, Dyess DL, Collins JN, Ardell JL, Townsley MI, Taylor AE. Effects of pentafraction (PZ) on microvascular permeability in burn injury. FASEB J. 1992; 6:A2038.

67. Weidner WJ, McClure D, Townsley MI. Alteration of lymphatic protein concentration during transit in the caudal mediastinal lymph node (CMN). FASEB J. 1992; 6:A2039.

68. Dyess DL, Collins JN, Townsley MI, Ardell JL, Luterman A, Taylor AE, Ferrara JJ. The effects of lazaroids on capillary permeability at the site of burn injury. Proc. Am. Burn Assoc. 1992; 24:7.

69. Townsley MI, Reed RK, Ishibashi M, Taylor AE, Laurent TC. Enhanced washout of lung hyaluronan following saline loading in anesthetized dogs. Int. J. Microcirc. 1992; 11:S81.

70. Townsley MI, Zhao Z, Ishibashi M. Reflection coefficient (F_d) and permeability-surface area product (PS) in canine lung and paw after saline loading. FASEB J. 1993; 7:A905.

71. Townsley MI, Pitts VH. Interaction of pulmonary "₂-adrenergic receptors with endothelial nitric oxide (NO) synthase in normal or pacing-induced heart failure dogs. FASEB J. 1993; 7:A788.

72. Kothandapani R, Rodt SÅ, Ardell JL, Townsley MI. Pulmonary flow redistribution after unilateral hypoxic ventilation in dogs after pacing-induced heart failure. FASEB J. 1993; 7:A543.

73. Roy BJ, Townsley MI. Pulmonary vascular responses to angiotensin II (AII) in pacing-induced heart failure dogs. FASEB J. 1993; 7:A543.

74. McMillon RK, Tran T, Townsley MI. Effect of pacing-induced heart failure (HF) on norepinephrine vasoreactivity of isolated bronchial vessels in canine lung. FASEB J. 1993; 7:A540.

75. Halstead MC, Townsley MI. Enhanced pulmonary vasoconstriction with acetylcholine (ACh) in canine pacing-induced heart failure (HF). FASEB J. 1993; 7:A651.

76. Negrini D, Venturoli D, Townsley MI, Taylor AE, Reed RK. Permselectivity of the parietal pleura in spontaneously breathing mammals. FASEB J. 1993; 7:A896.

77. Dyess D, Ardell JL, Townsley MI, Ferrara JJ, Taylor AE. Microvascular hemodynamic and permeability alterations in thermal injury: effects of lazaroid U74389-F. FASEB J. 1993; 7:A557.

78. Rodt SÅ, Reed RK, Townsley MI. Prenodal hyaluronan flux from dog paw skin during increased interstitial fluid flux induced by histamine or mast cell degranulation. FASEB J. 1993; 7:A538.

79. Townsley MI, Reed RK, Ardell JL, Laurent TC. Lung, heart and skin interstitial matrix composition following development of pacing-induced heart failure. Proc. XXXII Cong. Int. Union Physiol. Sci. 1993; 323.8.

80. Parker JC, Ardell JL, Hamm CR, Townsley MI, Coker PJ. Gravity dependent and independent pulmonary blood flow gradients in unanesthetized dogs. Proc. XXXII Cong. Int. Union Physiol. Sci. 1993; 281.14.

81. Parker JC, Ardell JL, Hamm CR, Townsley MI, Coker PJ. Fractal properties and gravity dependent gradients of pulmonary blood flow in exercising dogs. FASEB J. 1994; 8:A914.

82. Townsley MI, Pitts VH. Stress failure of pulmonary capillaries after induction of pacing-induced heart failure in dogs. FASEB J. 1994; 8:A1060.

83. Townsley MI, Jordan MA, Pitts VH, Barnes S, Halstead MC. Pulmonary vasoconstriction with serotonin, norepinephrine, and histamine following development of canine pacing-induced heart failure of varying duration. Pathophysiol. 1994; 1 (Suppl.):402.

84. Townsley MI, Pitts VH. Modulation of adrenergic vasoconstriction by neuronal norepinephrine (NE) reuptake, prostaglandins, and nitric oxide (NO) in normal canine lung. Microcirculation 1995; 2:92.

85. McMillon RK, Townsley MI. "-Adrenergic vasoreactivity of canine intrapulmonary bronchial arteries in heart failure (HF). Microcirculation 1995; 2:92.

86. Lee AK, Townsley MI. Modulation of oleic acid injury in isolated canine lungs with isoproterenol. Microcirculation 1995; 2:88.

87. McMillon MI, Townsley MI. Endothelial modulation of "-adrenergic vasoreactivity in intrapulmonary bronchial arteries. FASEB J. 1995; 9:A556.

88. Townsley MI, Erlanson-Albertsson C, Ohlsson A, Reed RK. Enterostatin efflux in cat intestinal lymph: relation to lymph flow, hyaluronan and fat absorption. FASEB J. 1995; 9:A367.

89. Lee AK, Townsley MI. Lung microvascular permeability after oleic acid in pacing-induced heart failure. J. Mol. Cell. Cardiol. 1995; 27:A16.

90. Townsley MI, Fu Z, Mathieu-Costello O, West JB. Morphometric analysis of canine lung after pacing-induced heart failure. J. Mol. Cell. Cardiol. 1995; 27:A11.

91. McMillon RK, Townsley MI. Endothelial nitric oxide and "-adrenergic vasoreactivity in intrapulmonary bronchial arteries. J. Mol. Cell. Cardiol. 1995; 27:A54.

92. McMillon RK, Townsley MI. "α₂-Adrenoreceptor-mediated vasoreactivity in canine isolated intrapulmonary bronchial arteries. FASEB J. 1996; 10:A111.

93. Lee AK, Townsley MI. Enhanced alveolar fluid clearance in a canine model of pacing-induced heart failure. FASEB J. 1996; 10:A354.

94. Townsley MI, Mathieu-Costello O. Morphometric evaluation of the pulmonary vasculature in canine pacing-induced heart failure. Int. J. Microcirc. 1996; 16:235.

95. McMillon RK, Townsley MI. Endothelial NO and "-adrenergic vasoreactitivy of bronchial arteries in canine pacing-induced heart failure. Microcirculation 1997; 4:170.

96. Ivey CL, Townsley MI. The effects of thapsigargin on pulmonary vasculature in canine pacing-induced heart failure. Microcirculation 1997; 4:149.

97. McMillon RK, Townsley MI. Effects of L-arginine or sodium nitroprusside in norepinephrine (NE)-constricted bronchial arteries. J. Mol. Cell. Cardiol. 1997; 29:A219.

98. Ivey CL, Townsley MI. The effect of pacing-induced heart failure on pulmonary interstitial pressure vs fluid relationship. J. Mol. Cell. Cardiol. 1997; 29:A167.

99. Townsley MI. Adaptations in lung are critical for limitation of pulmonary edema in pacing-induced heart failure. J. Mol. Cell. Cardiol. 1997; 29:A249.

100. Townsley MI, Ivey CL, Stephenson AH. Do altered P450 activity or elevated cyclic AMP explain the insensitivity of lung endothelium to injury after pacing-induced heart failure? FASEB J. 1998; 12: A27.

101. Ivey CL, Stephenson AH, Townsley MI. Involvement of cytochrome P-450 pathway in pulmonary microvascular permeability. FASEB J. 1998; 12: A24.

102. McMillon RK, Townsley MI. Effects of canine pacing-induced heart failure on acetylcholine- and sodium nitroprusside-mediated relaxations of intrapulmonary bronchial arteries. FASEB J. 1998; 12: A383.

103. Dyess DL, Hunter JL, Lakey JR, Townsley MI. Endogenous catecholamines attenuate histamine-induced permeability responses after heart failure. FASEB J. 1999; 13: A89.

104. Townsley MI, Leuwerke S, Jacobs ER. Depressed EET synthesis does not explain enhanced pressor response to norepinephrine (NE) after heart failure (HF). FASEB J. 1999; 13: A500.